2-{二甲基(2-噻吩基)硅烷基}苄醇合成路线 （共 9 条）
反应条件
copper(l) iodide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct; potassium carbonate in tetrahydrofuran; N,N-dimethyl-formamide T=75°C; 4 h; Inert atmosphere;
参考文献
Bulletin of the Chemical Society of Japan, , vol. 83, # 5 p. 554 - 569
反应条件
1: thien-2-yl bromide With magnesium
2: 1,1-dimethyl-1,3-dihydrobenzo[c][1,2]oxasilole in tetrahydrofuran
T=0 - 20°C; 22 h;
3: With water; ammonium chloride in tetrahydrofuran; diethyl ether
参考文献
Nakao, Yoshiaki; Hiyama, Tamejiro
Patent: US2009/69577 A1, 2009 ;
Location in patent: Page/Page column 15-16 ;
反应条件
in tetrahydrofuran
T=20°C; 22 h;
参考文献
Nakao, Yoshiaki; Imanaka, Hidekazu; Sahoo, Akhila K.; Yada, Akira; Hiyama, Tamejiro
Journal of the American Chemical Society, 2005 , vol. 127, # 19 p. 6952 - 6953
反应条件
1.1: n-BuLi / tetrahydrofuran; hexane / 0.83 h / -78 °C
1.2: 38 g / tetrahydrofuran; hexane / -78 - 20 °C
2.1: 83 percent / p-toluenesulfonic acid*H2O / methanol / 16 h / 20 °C
3.1: 79 percent / tetrahydrofuran / 22 h / 20 °C
View Scheme
参考文献
Nakao, Yoshiaki; Imanaka, Hidekazu; Sahoo, Akhila K.; Yada, Akira; Hiyama, Tamejiro
Journal of the American Chemical Society, 2005 , vol. 127, # 19 p. 6952 - 6953
反应条件
1.1: aq. HCl / 20 °C
2.1: n-BuLi / tetrahydrofuran; hexane / 0.83 h / -78 °C
2.2: 38 g / tetrahydrofuran; hexane / -78 - 20 °C
3.1: 83 percent / p-toluenesulfonic acid*H2O / methanol / 16 h / 20 °C
4.1: 79 percent / tetrahydrofuran / 22 h / 20 °C
View Scheme
参考文献
Nakao, Yoshiaki; Imanaka, Hidekazu; Sahoo, Akhila K.; Yada, Akira; Hiyama, Tamejiro
Journal of the American Chemical Society, 2005 , vol. 127, # 19 p. 6952 - 6953
反应条件
copper(l) iodide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct; potassium carbonate in tetrahydrofuran; N,N-dimethyl-formamide
T=75°C; 6 h; Inert atmosphere;
参考文献
Chen, Jinshui; Tanaka, Masaaki; Sahoo, Akhila K.; Takeda, Masahide; Yada, Akira; Nakao, Yoshiaki; Hiyama, Tamejiro
Bulletin of the Chemical Society of Japan, 2010 , vol. 83, # 5 p. 554 - 569
反应条件
copper(l) iodide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct; potassium carbonate in tetrahydrofuran; N,N-dimethyl-formamide
T=50°C; 6 h; Inert atmosphere;
参考文献
Chen, Jinshui; Tanaka, Masaaki; Sahoo, Akhila K.; Takeda, Masahide; Yada, Akira; Nakao, Yoshiaki; Hiyama, Tamejiro
Bulletin of the Chemical Society of Japan, 2010 , vol. 83, # 5 p. 554 - 569
反应条件
copper(l) iodide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct; potassium carbonate in tetrahydrofuran; N,N-dimethyl-formamide
T=75°C; 4 h; Inert atmosphere;
参考文献
Chen, Jinshui; Tanaka, Masaaki; Sahoo, Akhila K.; Takeda, Masahide; Yada, Akira; Nakao, Yoshiaki; Hiyama, Tamejiro
Bulletin of the Chemical Society of Japan, 2010 , vol. 83, # 5 p. 554 - 569
反应条件
1,1'-bis-(diphenylphosphino)ferrocene; copper(I) bromide dimethylsulfide complex; Pd[P(o-tol)3]2; caesium carbonate in tetrahydrofuran; 1-methyl-pyrrolidin-2-one
T=50°C; Inert atmosphereMolecular sieve;
参考文献
Shimizu, Kenta; Minami, Yasunori; Nakao, Yoshiaki; Ohya, Ken-Ichiro; Ikehira, Hideyuki; Hiyama, Tamejiro
Chemistry Letters, 2013 , vol. 42, # 1 p. 45 - 47
