反应条件
1.1: 77 percent / i-PrOTMS; TMSOTf / CH2Cl2 / -78 °C
2.1: 85 percent / tetrahydrofuran / 24 h / Heating
3.1: 85 percent / Me2AlCl / CH2Cl2 / 0.17 h / -78 °C
4.1: LHMDS / tetrahydrofuran; hexane / 1.5 h / -78 - -10 °C
4.2: 70 percent / tetrahydrofuran; hexane / 3 h / -20 - 0 °C
5.1: 81 percent / NaBH4 / ethanol / 2.5 h / -78 °C
6.1: 95 percent / 2,6-lutidine / CH2Cl2 / 1 h / -10 °C
7.1: n-BuLi / tetrahydrofuran; pentane / 0.08 h / -78 °C
7.2: BF3*Et2O / tetrahydrofuran; pentane / 3 h / -78 °C
8.1: 57 percent / second generation Grubbs' catalyst / CH2Cl2 / 48 h / 50 - 55 °C
9.1: 89 percent / 2,6-lutidine; DMAP / pyridine / 1 h / 0 - 20 °C
10.1: 78 percent / pyridine; OsO4 / tetrahydrofuran / 5 h / 0 °C
11.1: 95 percent / pyridine / CH2Cl2 / 2 h / 0 °C
12.1: 84 percent / BnNMe3OH / methanol; tetrahydrofuran / 1 h / 0 °C
13.1: n-BuLi; WCl6 / tetrahydrofuran; hexane / 0 - 20 °C
14.1: 12 mg / pyridinum p-toluenesulfonate / methanol / 6 h / 0 °C
15.1: 69 percent / Dess-Martin periodinane; pyridine / CH2Cl2 / 0 - 20 °C
16.1: 40 percent / aq. HF / acetonitrile / 0 - 20 °C
View Scheme
参考文献
Smith III, Amos B.; Mesaros, Eugen F.; Meyer, Emmanuel A.
Journal of the American Chemical Society, 2005 , vol. 127, # 19 p. 6948 - 6949
