4-氯-2-甲基-1H-吡咯并[3,2-c]吡啶合成路线 （共 4 条）
反应条件
copper(l) iodide in DMF (N,N-dimethyl-formamide)
T=20 - 120°C; 24 h;
参考文献
OXAGEN LIMITED
Patent: WO2005/121141 A1, 2005 ;
Location in patent: Page/Page column 26-27 ;
WO 2005/121141 A1
反应条件
1: N-iodo-succinimide / N,N-dimethyl-formamide / 20 - 55 °C
2: tetrahydrofuran / 1 h / Cooling with ice
3: triethylamine; copper(l) iodide / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 5 h / 50 °C / Inert atmosphere; Cooling with acetone-dry ice
4: copper(l) iodide / N,N-dimethyl-formamide / 110 °C / Inert atmosphere
View Scheme
参考文献
Almirall, S.A.
Patent: EP2526945 A1, 2012 ;
EP 2526945 A1
反应条件
1: triethylamine; copper(l) iodide / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 5 h / 50 °C / Inert atmosphere; Cooling with acetone-dry ice
2: copper(l) iodide / N,N-dimethyl-formamide / 110 °C / Inert atmosphere
View Scheme
参考文献
Almirall, S.A.
Patent: EP2526945 A1, 2012 ;
EP 2526945 A1
反应条件
1: tetrahydrofuran / 1 h / Cooling with ice
2: triethylamine; copper(l) iodide / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 5 h / 50 °C / Inert atmosphere; Cooling with acetone-dry ice
3: copper(l) iodide / N,N-dimethyl-formamide / 110 °C / Inert atmosphere
View Scheme
参考文献
Almirall, S.A.
Patent: EP2526945 A1, 2012 ;
EP 2526945 A1
