反应条件
1: 70 percent / Br2, AcOH / 48 h / Ambient temperature
2: 87 percent / K2CO3 / dimethylformamide / 24 h / 60 °C
3: 1.) BuLi, CuBr*SMe2, 2.) Me3SiCl / 1.) Et2O, hexane, THF, -78 deg C, 1 h, 2.) THF, Et2O, hexane, -78 deg C, 1.5 h
4: 92 percent / Et3N*HF / tetrahydrofuran / 120 h / Ambient temperature
5: 50 percent / Jones reagent / acetone / 3 h / 0 - 20 °C
6: 1.) N-methylmorpholine, isobutyl chloroformate, 2.) N-hydroxy-2-thiopyridone, Et3N / 1.) THF, -15 deg C, 15 min, 2.) Et2O, THF, -15 deg C, 1 h
View Scheme
参考文献
Diaz, Adolfo; Siro, Jorge G.; Garcia-Navio, Jose L.; Vaquero, Juan J.; Alvarez-Builla, Julio
Synthesis, 1997 , # 5 p. 559 - 562
