4-羟基-6-甲基喹啉-3-羧酸乙酯合成路线 （共 7 条）
反应条件
in diphenylether T=220 - 250°C;
参考文献
El-Essawy, Farag A.; El-Sayed, Wael A.
Journal of Heterocyclic Chemistry, 2013 , vol. 50, # SUPPL.1 p. E1-E8
反应条件
1: 87 percent / 3 h / Heating 2: 75 percent / various solvent(s) / 1.15 h / Heating View Scheme
参考文献
Nucleosides and Nucleotides, , vol. 15, # 4 p. 889 - 898
反应条件
Gould-Jacob reaction; 0.0708333 h; Irradiation;
参考文献
Dave, Chaitanya G.; Joshipura, Hardik M.
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2002 , vol. 41, # 3 p. 650 - 652
反应条件
1: ethanol / Reflux 2: diphenylether / Reflux View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 46, # 4 p. 1448 - 1452
参考文献
Chen, Shuguang; Chen, Ran; He, Meizi; Pang, Ruifang; Tan, Zhiwu; Yang, Ming
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 5 p. 1948 - 1956
反应条件
trichlorophosphate T=110°C; 0.333333 h; Inert atmosphere;
参考文献
Goncalves, Victor; Brannigan, James A.; Whalley, David; Ansell, Keith H.; Saxty, Barbara; Holder, Anthony A.; Wilkinson, Anthony J.; Tate, Edward W.; Leatherbarrow, Robin J.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 7 p. 3578 - 3582
反应条件
1: 71 percent / POCl3 / 5 h / Heating
2: 2.) H2O, NaOH / 1.) xylene, reflux, 4 h, 2.) Et2O, 1 h
View Scheme
参考文献
Karolak-Wojciechowska, Janina; Lange, Jerzy; Ksiazek, Waldemar; Gniewosz, Malgorzata; Rump, Slawomir
Farmaco, 1998 , vol. 53, # 8-9 p. 579 - 585
