4-氯-6-甲基硫代-1H-吡唑并[3,4-d]嘧啶合成路线 （共 9 条）
反应条件
1: H2O; NH3 / 100 °C 2: aqueous H2O2; aqueous HCl View Scheme
参考文献
Robins
Journal of the American Chemical Society, 1957 , vol. 79, p. 6407,6412
反应条件
palladium on activated charcoal; ammonia Hydrogenation;
参考文献
Roche Palo Alto LLC
Patent: US2005/203091 A1, 2005 ;
Location in patent: Page/Page column 53 ;
反应条件
hydrazine hydrate; triethylamine in 1,4-dioxane
T=20°C; 5 h;
参考文献
Vignaroli, Giulia; Mencarelli, Martina; Sementa, Deborah; Crespan, Emmanuele; Kissova, Miroslava; Maga, Giovanni; Schenone, Silvia; Radi, Marco; Botta, Maurizio
ACS Combinatorial Science, 2014 , vol. 16, # 4 p. 168 - 175
反应条件
N,N-dimethyl-aniline; trichlorophosphate
参考文献
Kim, Dong Chan; Lee, Yeo Ran; Yang, Beom-Seok; Shin, Kye Jung; Kim, Dong Jin; Chung, Bong Young; Yoo, Kyung Ho
European Journal of Medicinal Chemistry, 2003 , vol. 38, # 5 p. 525 - 532
反应条件
1: aq. NaOH solution
2: N,N-dimethyl-aniline; POCl3
View Scheme
参考文献
Robins
Journal of the American Chemical Society, 1956 , vol. 78, p. 784,787
Journal of the American Chemical Society, 1957 , vol. 79, p. 6407,6413
反应条件
1.1: trichlorophosphate / 1 h / 20 °C / |Cooling with ice; |Inert atmosphere
1.2: 12 h / |Reflux; |Inert atmosphere
2.1: triethylamine; hydrazine hydrate / 1,4-dioxane / 5 h / 20 °C
View Scheme
参考文献
Vignaroli, Giulia; Mencarelli, Martina; Sementa, Deborah; Crespan, Emmanuele; Kissova, Miroslava; Maga, Giovanni; Schenone, Silvia; Radi, Marco; Botta, Maurizio
ACS Combinatorial Science, 2014 , vol. 16, # 4 p. 168 - 175
反应条件
N-ethyl-N,N-diisopropylamine in butan-1-ol
T=50°C; 24 h;
参考文献
Kim, Dong Chan; Lee, Yeo Ran; Yang, Beom-Seok; Shin, Kye Jung; Kim, Dong Jin; Chung, Bong Young; Yoo, Kyung Ho
European Journal of Medicinal Chemistry, 2003 , vol. 38, # 5 p. 525 - 532
参考文献
Robins
Journal of the American Chemical Society, 1957 , vol. 79, p. 6407,6412
反应条件
ammonia; water
T=100°C;
参考文献
Robins
Journal of the American Chemical Society, 1957 , vol. 79, p. 6407,6412
Full Text Show Details
Robins
Journal of the American Chemical Society, 1956 , vol. 78, p. 784,787
Journal of the American Chemical Society, 1957 , vol. 79, p. 6407,6413
