4-(4-羟基丁基)苯甲酸乙酯合成路线 （共 3 条）
反应条件
1: With borane-THF in tetrahydrofuran
T=0 - 20°C; 2 h;
2: With water; potassium carbonate in tetrahydrofuran
T=0°C;
参考文献
Kissei Pharmaceutical Co., Ltd.
Patent: EP1813611 A1, 2007 ;
Location in patent: Page/Page column 25-26 ;
反应条件
copper monoiodide; triethylamine in ethyl acetate
参考文献
Tobishi Yakuhin Kogyo Kabushiki Kaisha
Patent: US5093370 A1, 1992 ;
反应条件
N,N,N',N',N'',N''-hexamethylphosphoric triamide; n-butyllithium; sulfuric acid; diisopropylamine
Yield given. Multistep reaction;
参考文献
Bicking, John B.; Robb, Charles M.; Cragoe, Edward J.; Blaine, Edward H.; Watson, L. Sherman; Dunlay, Mary C.
Journal of Medicinal Chemistry, 1983 , vol. 26, # 3 p. 335 - 341
