2-甲基-3,5-二硝基-苯甲酸乙酯合成路线 （共 7 条）
反应条件
1: aqueous ammonia 2: sodium hypochlorite / und Erwaermen des Reaktionsprodukts mit Wasser View Scheme
参考文献
McGookin; Swift; Tittensor
Journal of the Society of Chemical Industry, London, 1940 , vol. 59, p. 92,94
参考文献
McGookin; Swift; Tittensor
Journal of the Society of Chemical Industry, London, 1940 , vol. 59, p. 92,94
反应条件
1: 3,5-dinitro-2-methyl benzoic acid With thionyl chloride
4 h; Heating / reflux;
2: ethanol in dichloromethane
T=20°C; 1 h;
参考文献
Hadida Ruah, Sara S.; Grootenhuis, Peter D.J.; Van Goor, Frederick; Zhou, Jinglan; Bear, Brian; Miller, Mark T.; McCartney, Jason; Numa, Mehdi Michel Jamel
Patent: US2007/244159 A1, 2007 ;
Location in patent: Page/Page column 146 ;
反应条件
1: 3,5-dinitro-2-methyl benzoic acid With thionyl chloride
4 h; Reflux;
2: ethanol in dichloromethane
T=20°C; 1 h;
参考文献
Vertex Pharmaceuticals Incorporated
Patent: US2012/309758 A1, 2012 ;
Location in patent: Page/Page column 73 ;
US 20120309758 A1
反应条件
in thionyl chloride; ethanol; dichloromethane
参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;
Title/Abstract Full Text Show Details
Vertex Pharmaceuticals Incorporated
Patent: US2012/309758 A1, 2012 ;
US 20120309758 A1
反应条件
1: sulfuric acid; nitric acid
2: phosphorus (V)-chloride
3: ethanol
View Scheme
参考文献
McGookin; Swift; Tittensor
Journal of the Society of Chemical Industry, London, 1940 , vol. 59, p. 92,94
参考文献
McGookin; Swift; Tittensor
Journal of the Society of Chemical Industry, London, 1940 , vol. 59, p. 92,94
