in acetonitrile T=-30 - 25°C;

potassium hydroxide in dimethyl sulfoxide T=60°C; 22 h;

1: 81 percent / CH2Cl2 / -30 - -20 °C 2: 66 percent / acetonitrile / -30 - 25 °C View Scheme

1: 95 percent / Et3N / benzene / 3 h / Heating 2: 73 percent / 1.6M BuLi / pentane; diethyl ether / 1 h / -30 °C View Scheme

1: benzoyl peroxide / 22 h / Heating 2: 78 percent / tert-BuOK / 2-methyl-propan-2-ol / 5 h / 50 °C View Scheme

1: potassium carbonate / methanol / 2.5 h / 0 - 20 °C 2: n-butyllithium / tetrahydrofuran; hexane / 2.5 h / -78 - 20 °C / |Inert atmosphere; |Schlenk technique View Scheme

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / |Inert atmosphere; |Schlenk technique 1.2: 1.5 h / 20 °C / |Inert atmosphere; |Schlenk technique 2.1: potassium carbonate / methanol / 2.5 h / 0 - 20 °C 3.1: n-butyllithium / tetrahydrofuran; hexane / 2.5 h / -78 - 20 °C / |Inert atmosphere; |Schlenk technique View Scheme

potassium hydroxide in dimethyl sulfoxide 1 h; Ambient temperature;