甲基[4-(氯甲酰基)苯基]乙酸酯合成路线 （共 3 条）
反应条件
thionyl chloride in dichloromethane
T=50°C; 18 h;
参考文献
Ceccarelli, Simona M.; Chomienne, Odile; Mattei, Patrizio; Sander, Ulrike Obst
Patent: US2008/153805 A1, 2008 ;
Location in patent: Page/Page column 15 ;
反应条件
in dichloromethane
T=20°C; 2 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2005/12220 A2, 2005 ;
Location in patent: Page/Page column 113-114 ;
WO 2005/012220 A2
反应条件
aluminium trichloride
T=5 - 10°C; Friedel-Crafts reaction;
参考文献
Salem, Ola I. A.; Frotscher, Martin; Scherer, Christiane; Neugebauer, Alexander; Biemel, Klaus; Streiber, Martina; Maas, Ruth; Hartmann, Rolf W.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 2 p. 748 - 759
