(S)-5-氨基-2-(Boc-氨基)-5-酮基戊酸合成路线 （共 3 条）
反应条件
4-(N,N-dimethlyamino)pyridine; triethylamine; 1,1'-carbonyldiimidazole in tetrahydrofuran T=20°C; 72 h;
参考文献
Nakamura, Takanori; Noguchi, Tomomi; Kobayashi, Hisayoshi; Miyachi, Hiroyuki; Hashimoto, Yuichi
Chemical and Pharmaceutical Bulletin, 2006 , vol. 54, # 12 p. 1709 - 1714
Title/Abstract Full Text View citing articles Show Details
Nakamura, Takanori; Noguchi, Tomomi; Miyachi, Hiroyuki; Hashimoto, Yuichi
Chemical and Pharmaceutical Bulletin, 2007 , vol. 55, # 4 p. 651 - 654
反应条件
triethylamine in methanol
T=20°C; 1 h;
参考文献
Hioki, Kazuhito; Kinugasa, Mizuho; Kishimoto, Michiko; Fujiwara, Miho; Tani, Shohei; Kunishima, Munetaka
Synthesis, 2006 , # 12 p. 1931 - 1933
反应条件
1: 90 percent / 1,1'-carbonyldiimidazole; 4-dimethylaminopyridine; triethylamine / tetrahydrofuran / 72 h / 20 °C
2: 98 percent / HBr; AcOH / 0.5 h / 20 °C
3: 98 percent / N-ethyl-N'-(3-dimethylaminopropyl)carbodiimide hydrochloride; 1-hydroxybenzotriazole monohydrate; TEA / CH2Cl2 / 72 h / 20 °C
4: 59 percent / H2; acetic acid / Pd/C / ethyl acetate / 1 h / 20 °C
View Scheme
参考文献
Nakamura, Takanori; Noguchi, Tomomi; Kobayashi, Hisayoshi; Miyachi, Hiroyuki; Hashimoto, Yuichi
Chemical and Pharmaceutical Bulletin, 2006 , vol. 54, # 12 p. 1709 - 1714
