1.1: sodium methylate / N,N-dimethyl-formamide; methanol / 1 h / -10 °C 1.2: 20 °C 2.1: sodium hydroxide / tetrahydrofuran; methanol / 25 h / 5 - 20 °C / Industry scale 2.2: Industry scale View Scheme

1.1: sodium methylate / N,N-dimethyl-formamide; methanol / 1 h / -10 °C 1.2: 20 °C 2.1: sodium hydroxide / tetrahydrofuran; methanol / 25 h / 5 - 20 °C / Industry scale 2.2: Industry scale 3.1: sodium hydroxide / toluene; ethanol / 2.5 h / 0 - 30 °C / Industry scale View Scheme