4-[3-(三氟甲基)-3H-双吖丙啶-3-基]苯甲酸合成路线 （共 34 条）
反应条件
1: 92 percent / Ag2O / diethyl ether / 1 h 2: 86 percent / TFA / CH2Cl2 / 2 h / Ambient temperature 3: 72 percent / 0.2N KOH, KMnO4 / dioxane / 2 h / Ambient temperature View Scheme
参考文献
Liebigs Annalen der Chemie, , # 9 p. 1510 - 1523
反应条件
1: 93 percent / NH3OHCl, NaOH / ethanol / 16 h / Heating 2: 70 percent / pyridine / 3 h / Heating 3: 86 percent / liq. NH3 / diethyl ether / 12 h / Ambient temperature 4: 91 percent / Ag2O / diethyl ether / 1 h 5: 92 percent / conc. HCl / methanol 6: 72 percent / 0.2N KOH, KMnO4 / dioxane / 2 h / Ambient temperature View Scheme
参考文献
Liebigs Annalen der Chemie, , # 9 p. 1510 - 1523
反应条件
1: 92 percent / conc. HCl / methanol 2: 72 percent / 0.2N KOH, KMnO4 / dioxane / 2 h / Ambient temperature View Scheme
参考文献
Liebigs Annalen der Chemie, , # 9 p. 1510 - 1523
反应条件
1: 91 percent / Ag2O / diethyl ether / 1 h 2: 92 percent / conc. HCl / methanol 3: 72 percent / 0.2N KOH, KMnO4 / dioxane / 2 h / Ambient temperature View Scheme
参考文献
Liebigs Annalen der Chemie, , # 9 p. 1510 - 1523
反应条件
1: 87 percent / pyridine / 3 h / Heating 2: 80 percent / NH3 / diethyl ether / 12 h / Ambient temperature 3: 92 percent / Ag2O / diethyl ether / 1 h 4: 86 percent / TFA / CH2Cl2 / 2 h / Ambient temperature 5: 72 percent / 0.2N KOH, KMnO4 / dioxane / 2 h / Ambient temperature View Scheme
参考文献
Liebigs Annalen der Chemie, , # 9 p. 1510 - 1523
反应条件
1: 70 percent / pyridine / 3 h / Heating 2: 86 percent / liq. NH3 / diethyl ether / 12 h / Ambient temperature 3: 91 percent / Ag2O / diethyl ether / 1 h 4: 92 percent / conc. HCl / methanol 5: 72 percent / 0.2N KOH, KMnO4 / dioxane / 2 h / Ambient temperature View Scheme
参考文献
Liebigs Annalen der Chemie, , # 9 p. 1510 - 1523
反应条件
1: 80 percent / NH3 / diethyl ether / 12 h / Ambient temperature 2: 92 percent / Ag2O / diethyl ether / 1 h 3: 86 percent / TFA / CH2Cl2 / 2 h / Ambient temperature 4: 72 percent / 0.2N KOH, KMnO4 / dioxane / 2 h / Ambient temperature View Scheme
参考文献
Liebigs Annalen der Chemie, , # 9 p. 1510 - 1523
反应条件
1: 86 percent / liq. NH3 / diethyl ether / 12 h / Ambient temperature 2: 91 percent / Ag2O / diethyl ether / 1 h 3: 92 percent / conc. HCl / methanol 4: 72 percent / 0.2N KOH, KMnO4 / dioxane / 2 h / Ambient temperature View Scheme
参考文献
Liebigs Annalen der Chemie, , # 9 p. 1510 - 1523
反应条件
trifluoroacetic acid in dichloromethane 2 h;
参考文献
Bioconjugate Chemistry, , vol. 21, # 2 p. 352 - 359
反应条件
sodium hydroxide; magnesium oxide; trifluoroacetic acid; lithium chloride; Tl(OCOCF3)3; palladium dichloride 1.) 75 deg C, 24 h; 2.) r.t., 24 h; 3.) MeOH, r.t., 2 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Heterocycles, , vol. 43, # 3 p. 519 - 522
