4-[3-(三氟甲基)-3H-双吖丙啶-3-基]苯甲酸合成路线 （共 34 条）
反应条件
sodium hydroxide; methyl iodide 1.) DMF, 60 deg C, 20 h, 2.) water, RT, 6 h; Yield given. Multistep reaction;
参考文献
Heterocycles, , vol. 35, # 2 p. 997 - 1004
反应条件
dicyclohexyl-carbodiimide in dichloromethane 2 h;
参考文献
Heterocycles, , vol. 43, # 3 p. 519 - 522
反应条件
diborane in tetrahydrofuran T=-5°C; 5 h;
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 16 p. 4818 - 4825
反应条件
1: 95 percent / cyanuric fluoride, pyridine / CH2Cl2 / 2 h / -20 - -10 °C
2: 84 percent / LiBH4 / tetrahydrofuran; methanol / 1 h / Ambient temperature
3: 91 percent / CBr4, PPh3 / CH2Cl2 / 2 h / Ambient temperature
View Scheme
参考文献
Latli, Bachir; Morimoto, Hiromi; Williams, Philip G.; Casida, John E.
Journal of Labelled Compounds and Radiopharmaceuticals, 1998 , vol. 41, # 3 p. 191 - 199
