1: (diethylamino)(4-methoxyphenyl)acetonitrile With sodium hydride in DMF (N,N-dimethyl-formamide) T=20°C; 1 h; 2: benzyl chloride in DMF (N,N-dimethyl-formamide) T=20°C; 3: With hydrogenchloride; methanol; water more than 3 stages;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2004/11410 A1, 2004 ;
Location in patent: Page 78-79 ;
WO 2004/011410 A1