1-溴-4-甲氧基-2-甲基-3-硝基苯合成路线 （共 9 条）
反应条件
1: pyrrolidine / dimethylformamide / 14 h / 110 °C 2: NH2NH2*H2O; Raney-Ni / methanol; tetrahydrofuran View Scheme
参考文献
Oikawa, Masato; Ikoma, Minoru; Sasaki, Makoto
European Journal of Organic Chemistry, 2011 , # 24 p. 4654 - 4666
反应条件
1: With pyrrolidine in N,N-dimethyl-formamide T=90°C; 18 h; 2: With iron; acetic acid 1 h; Reflux; 3: With sodium carbonate in water
参考文献
SAREUM LIMITED; READER, John Charles
Patent: WO2013/117522 A1, 2013 ;
Location in patent: Page/Page column 41-42 ;
反应条件
potassium carbonate
Heating;
参考文献
Yang, Cai-Guang; Wang, Jun; Jiang, Biao
Tetrahedron Letters, 2002 , vol. 43, # 6 p. 1063 - 1066
反应条件
bromine; acetic acid
T=20°C;
参考文献
WYETH
Patent: WO2009/111260 A1, 2009 ;
Location in patent: Page/Page column 35 ;
WO 2009/111260 A1
反应条件
1: 98 percent / Br2 / acetic acid / 6 h
2: 100 percent / K2CO3 / Heating
View Scheme
参考文献
Yang, Cai-Guang; Wang, Jun; Jiang, Biao
Tetrahedron Letters, 2002 , vol. 43, # 6 p. 1063 - 1066
反应条件
nitric acid; acetic anhydride
T=0°C; 1 h; regioselective reaction;
参考文献
Radchenko, Oleg S.; Sigida, Elena N.; Balaneva, Nadezhda N.; Dmitrenok, Pavel S.; Novikov, Vyacheslav L.
Journal of Heterocyclic Chemistry, 2011 , vol. 48, # 1 p. 209 - 214
反应条件
1.1: H2SO4 (98 percent) / 26 h / 20 °C
1.2: 59 percent / HNO3; H2SO4 / 2 h / 0 °C
2.1: 98 percent / Br2 / acetic acid / 6 h
3.1: 100 percent / K2CO3 / Heating
View Scheme
参考文献
Yang, Cai-Guang; Wang, Jun; Jiang, Biao
Tetrahedron Letters, 2002 , vol. 43, # 6 p. 1063 - 1066
反应条件
sodium hydroxide in water
Heating;
参考文献
Cannon; Lukszo; Max
Journal of Heterocyclic Chemistry, 1983 , vol. 20, # 1 p. 149 - 153
反应条件
iron; ammonium chloride in ethanol; water
1.16667 h; HeatingReflux;
参考文献
WYETH
Patent: WO2009/111260 A1, 2009 ;
Location in patent: Page/Page column 35-36 ;
WO 2009/111260 A1
