4-苄氧基-2-甲氧基苯甲酸合成路线 （共 8 条）
反应条件
potassium hydroxide in methanol
Heating;
参考文献
Astles; Brown; Handscombe; Harper; Harris; Lewis; Lockey; McCarthy; McLay; Porter; Roach; Smith; Walsh
European Journal of Medicinal Chemistry, 1997 , vol. 32, # 5 p. 409 - 423
反应条件
sodium hydroxide; water in ethanol
60 h; Heating / reflux;
参考文献
Barber, Christopher Gordon; Bunnage, Mark Edward; Harvey, John Wilson; Mathias, John Paul
Patent: US2005/20611 A1, 2005 ;
Location in patent: Page/Page column 40 ;
反应条件
1: 84 percent / KI, Bu4NCl, K2CO3 / acetone / 7 h / Heating
2: 1.) NaH / 1.) DMF, 10 min, 2.) 100 deg C
3: KOH / methanol / Heating
View Scheme
参考文献
Astles; Brown; Handscombe; Harper; Harris; Lewis; Lockey; McCarthy; McLay; Porter; Roach; Smith; Walsh
European Journal of Medicinal Chemistry, 1997 , vol. 32, # 5 p. 409 - 423
反应条件
1: 1.) NaH / 1.) DMF, 10 min, 2.) 100 deg C
2: KOH / methanol / Heating
View Scheme
参考文献
Astles; Brown; Handscombe; Harper; Harris; Lewis; Lockey; McCarthy; McLay; Porter; Roach; Smith; Walsh
European Journal of Medicinal Chemistry, 1997 , vol. 32, # 5 p. 409 - 423
反应条件
1: 84 percent / KI, Bu4NCl, K2CO3 / acetone / 7 h / Heating
2: 1.) NaH / 1.) DMF, 10 min, 2.) 100 deg C
3: KOH / methanol / Heating
View Scheme
参考文献
Astles; Brown; Handscombe; Harper; Harris; Lewis; Lockey; McCarthy; McLay; Porter; Roach; Smith; Walsh
European Journal of Medicinal Chemistry, 1997 , vol. 32, # 5 p. 409 - 423
反应条件
sodium hydroxide; trichlorophosphate
参考文献
Dr. Karl Thomae GmbH
Patent: US4582837 A1, 1986 ;
反应条件
hydrogen; 30 Pd/C in methanol
T=20°C; P=3102.97 Torr; 24 h;
参考文献
Barber, Christopher Gordon; Bunnage, Mark Edward; Harvey, John Wilson; Mathias, John Paul
Patent: US2005/20611 A1, 2005 ;
Location in patent: Page/Page column 40 ;
反应条件
piperazine in N,N-dimethyl acetamide
T=150°C; Substitution; 0.2 h;
参考文献
Nishioka, Hiroyasu; Nagasawa, Masaaki; Yoshida, Kiyoshi
Synthesis, 2000 , # 2 p. 243 - 246
