(3S)-boc-3-氨基-4-苯基-2-丁酮合成路线 （共 18 条）
反应条件
1.1: Dess-Martin periodinane / CH2Cl2 / 3 h / 0 - 20 °C 1.2: 2-methyl-2-butene; NaClO2; NaH2PO4*H2O / tetrahydrofuran; H2O / 5 h / 0 - 20 °C 1.3: HOBt; EDC; triethylamine / CHCl3 / 36 h / 20 °C 2.1: O3 / CH2Cl2; methanol / -78 °C 2.2: 83 percent / Me2S / CH2Cl2; methanol / -78 - 20 °C View Scheme
参考文献
Organic Letters, , vol. 8, # 21 p. 4731 - 4734
反应条件
1.1: Cp2ZrHCl / CH2Cl2 / 0.33 h / 20 °C 1.2: Me2Zn / toluene; CH2Cl2 / -78 - 0 °C 1.3: 64 percent / CH2Cl2; toluene / 2 h / 0 °C 2.1: 47 percent / TBAF / tetrahydrofuran / 0 - 20 °C 3.1: Dess-Martin periodinane / CH2Cl2 / 3 h / 0 - 20 °C 3.2: 2-methyl-2-butene; NaClO2; NaH2PO4*H2O / tetrahydrofuran; H2O / 5 h / 0 - 20 °C 3.3: HOBt; EDC; triethylamine / CHCl3 / 36 h / 20 °C 4.1: O3 / CH2Cl2; methanol / -78 °C 4.2: 83 percent / Me2S / CH2Cl2; methanol / -78 - 20 °C View Scheme
参考文献
Organic Letters, , vol. 8, # 21 p. 4731 - 4734
反应条件
1.1: 47 percent / TBAF / tetrahydrofuran / 0 - 20 °C 2.1: Dess-Martin periodinane / CH2Cl2 / 3 h / 0 - 20 °C 2.2: 2-methyl-2-butene; NaClO2; NaH2PO4*H2O / tetrahydrofuran; H2O / 5 h / 0 - 20 °C 2.3: HOBt; EDC; triethylamine / CHCl3 / 36 h / 20 °C 3.1: O3 / CH2Cl2; methanol / -78 °C 3.2: 83 percent / Me2S / CH2Cl2; methanol / -78 - 20 °C View Scheme
参考文献
Organic Letters, , vol. 8, # 21 p. 4731 - 4734
反应条件
1.1: 61 percent / diethyl ether / 20 °C 2.1: Cp2ZrHCl / CH2Cl2 / 0.33 h / 20 °C 2.2: Me2Zn / toluene; CH2Cl2 / -78 - 0 °C 2.3: 64 percent / CH2Cl2; toluene / 2 h / 0 °C 3.1: 47 percent / TBAF / tetrahydrofuran / 0 - 20 °C 4.1: Dess-Martin periodinane / CH2Cl2 / 3 h / 0 - 20 °C 4.2: 2-methyl-2-butene; NaClO2; NaH2PO4*H2O / tetrahydrofuran; H2O / 5 h / 0 - 20 °C 4.3: HOBt; EDC; triethylamine / CHCl3 / 36 h / 20 °C 5.1: O3 / CH2Cl2; methanol / -78 °C 5.2: 83 percent / Me2S / CH2Cl2; methanol / -78 - 20 °C View Scheme
参考文献
Organic Letters, , vol. 8, # 21 p. 4731 - 4734
反应条件
1.1: 61 percent / diethyl ether / 20 °C 2.1: Cp2ZrHCl / CH2Cl2 / 0.33 h / 20 °C 2.2: Me2Zn / toluene; CH2Cl2 / -78 - 0 °C 2.3: 64 percent / CH2Cl2; toluene / 2 h / 0 °C 3.1: 47 percent / TBAF / tetrahydrofuran / 0 - 20 °C 4.1: Dess-Martin periodinane / CH2Cl2 / 3 h / 0 - 20 °C 4.2: 2-methyl-2-butene; NaClO2; NaH2PO4*H2O / tetrahydrofuran; H2O / 5 h / 0 - 20 °C 4.3: HOBt; EDC; triethylamine / CHCl3 / 36 h / 20 °C 5.1: O3 / CH2Cl2; methanol / -78 °C 5.2: 83 percent / Me2S / CH2Cl2; methanol / -78 - 20 °C View Scheme
参考文献
Organic Letters, , vol. 8, # 21 p. 4731 - 4734
反应条件
in diethyl ether 18 h; Ambient temperature;
参考文献
Hamby, James M.; Hodges, John C.
Heterocycles, 1993 , vol. 35, # 2 p. 843 - 850
反应条件
1: lithium hexamethyldisilazane / tetrahydrofuran 2: N-bromosuccinmide / tetrahydrofuran / -40 °C 3: sodium tetrahydroborate / ethanol / -78 °C 4: potassium hydroxide / ethanol View Scheme
参考文献
Chemistry - A European Journal, , vol. 17, # 52 p. 14772 - 14784
反应条件
1: lithium hexamethyldisilazane / tetrahydrofuran 2: N-bromosuccinmide / tetrahydrofuran / -40 °C 3: sodium tetrahydroborate / ethanol / -78 °C 4: potassium hydroxide / ethanol View Scheme
参考文献
Chemistry - A European Journal, , vol. 17, # 52 p. 14772 - 14784
