4-(4-氯-3-硝基苯基)-3-甲基-4-氧代丁酸合成路线 （共 7 条）
反应条件
1.1: hydrazine hydrate; acetic acid / water 2.1: butan-1-ol; water 3.1: hydrogenchloride; hydrogen / palladium on carbon / water; methanol 4.1: sodium dithionite / N,N-dimethyl-formamide / 90 °C 4.2: 95 - 105 °C View Scheme
参考文献
NOVARTIS AG; SCHICKANEDER, Christian; RIEDEL, Michael; BISKUP, Kathrin; HEYDEMUeLLER, Heike; REINHARDT, Ingeborg
Patent: WO2011/124638 A1, 2011 ;
反应条件
1: 98 percent / hydrazine hydrate / acetic acid / 2.5 h / 100 °C 2: 86 percent / butan-1-ol / 20 h / Heating 3: 88.6 percent / H2, 1N aq. HCL / 5percent Pd/C / methanol / 2 h View Scheme
参考文献
NOVARTIS AG; SCHICKANEDER, Christian; RIEDEL, Michael; BISKUP, Kathrin; HEYDEMUeLLER, Heike; REINHARDT, Ingeborg
Patent: WO2011/124638 A1, 2011 ;
反应条件
hydrazine hydrate in acetic acid T=100°C; 2.5 h;
参考文献
Jonas, R; Klockow, M; Lues, I; Pruecher, H; Schliep, H J; Wurziger, H
European Journal of Medicinal Chemistry, 1993 , vol. 28, # 2 p. 129 - 140
反应条件
nitric acid
T=-15 - -10°C; 0.5 h;
参考文献
Jonas, R; Klockow, M; Lues, I; Pruecher, H; Schliep, H J; Wurziger, H
European Journal of Medicinal Chemistry, 1993 , vol. 28, # 2 p. 129 - 140
反应条件
1: sodium cyanide / dimethylformamide / 2 h / 40 °C
2: 54.6 percent / conc. HCl, water / Heating
3: 98 percent / nitric acid / 0.5 h / -15 - -10 °C
View Scheme
参考文献
Jonas, R; Klockow, M; Lues, I; Pruecher, H; Schliep, H J; Wurziger, H
European Journal of Medicinal Chemistry, 1993 , vol. 28, # 2 p. 129 - 140
反应条件
1: 54.6 percent / conc. HCl, water / Heating
2: 98 percent / nitric acid / 0.5 h / -15 - -10 °C
View Scheme
参考文献
Jonas, R; Klockow, M; Lues, I; Pruecher, H; Schliep, H J; Wurziger, H
European Journal of Medicinal Chemistry, 1993 , vol. 28, # 2 p. 129 - 140
反应条件
1: 98 percent / hydrazine hydrate / acetic acid / 2.5 h / 100 °C
2: 86 percent / butan-1-ol / 20 h / Heating
View Scheme
参考文献
NOVARTIS AG; SCHICKANEDER, Christian; RIEDEL, Michael; BISKUP, Kathrin; HEYDEMUeLLER, Heike; REINHARDT, Ingeborg
Patent: WO2011/124638 A1, 2011 ;
