1.1: hydrogenchloride / dichloromethane; water / pH 1.5 1.2: 0.75 h / 0 - 15 °C 2.1: potassium tert-butylate / toluene / 3 h / 20 °C 2.2: 3 h / 20 °C 3.1: phosphorous pentoxide; phosphoric acid / 96 h / 115 - 120 °C 4.1: formic acid; iodine; magnesium / toluene; methanol / 5 h / 20 - 40 °C 4.2: 5 - 10 °C / pH ~ 1 5.1: sodium tetrahydroborate / tetrahydrofuran / 0.25 h / 20 °C 5.2: 6 h / Reflux 5.3: 10 - 15 °C 6.1: isopropyl alcohol / 13.75 h / -10 - 65 °C View Scheme

1: AlCl3, aluminium chloride; lithium aluminium tetrahydride / tetrahydrofuran / 1 h / -25 - -20 °C 2: ethanol; tert-butyl methyl ether / 2 h / 0 - 20 °C View Scheme

sodium hydrogencarbonate in toluene T=25°C; 0.5 h;

biotransformation (Wistar rat);

biotransformation (Wistar rat);

biotransformation (Wistar rat);