(AR)-4-氯-2-氟-A-甲基苯甲胺合成路线 （共 3 条）
反应条件
hydrogenchloride in 1,4-dioxane; methanol
T=0 - 20°C; 18 h;
参考文献
CHEMOCENTRYX, INC.; LELETI, Manmohan Reddy; LI, Yandong; MALI, Venkat Reddy; POWERS, Jay; YANG, Ju
Patent: WO2013/82429 A1, 2013 ;
Location in patent: Paragraph 0118 ;
反应条件
1: L-Selectridereg; / tetrahydrofuran / 18 h / -45 - 20 °C
2: hydrogenchloride / methanol; 1,4-dioxane / 18 h / 0 - 20 °C
View Scheme
参考文献
CHEMOCENTRYX, INC.; LELETI, Manmohan Reddy; LI, Yandong; MALI, Venkat Reddy; POWERS, Jay; YANG, Ju
Patent: WO2013/82429 A1, 2013 ;
反应条件
1: titanium tetraethoxide / tetrahydrofuran / 18 h / 20 °C
2: L-Selectridereg; / tetrahydrofuran / 18 h / -45 - 20 °C
3: hydrogenchloride / methanol; 1,4-dioxane / 18 h / 0 - 20 °C
View Scheme
参考文献
CHEMOCENTRYX, INC.; LELETI, Manmohan Reddy; LI, Yandong; MALI, Venkat Reddy; POWERS, Jay; YANG, Ju
Patent: WO2013/82429 A1, 2013 ;
