2,6-二氨基-3-碘吡啶合成路线 （共 5 条）
反应条件
iodine; potassium carbonate in 2-methyl tetrahydrofuran
T=20°C; 3 h; Product distribution / selectivity;
参考文献
PFIZER LIMITED
Patent: WO2008/135826 A2, 2008 ;
Location in patent: Page/Page column 164 ;
WO 2008/135826 A2
反应条件
pyridine
T=20°C; 12 h;
参考文献
Sun, Zhenhua; Ahmed, Shahadat; McLaughlin, Larry W.
Journal of Organic Chemistry, 2006 , vol. 71, # 7 p. 2922 - 2925
反应条件
1: 85 percent / pyridine / 12 h / 20 °C
2: 64 percent / HBF4; NaNO2 / H2O / 2 h / -5 °C
View Scheme
参考文献
Sun, Zhenhua; Ahmed, Shahadat; McLaughlin, Larry W.
Journal of Organic Chemistry, 2006 , vol. 71, # 7 p. 2922 - 2925
反应条件
1: 85 percent / pyridine / 12 h / 20 °C
2: 64 percent / HBF4; NaNO2 / H2O / 2 h / -5 °C
3: 88 percent / H2SO4 / methanol; H2O / 12 h / 25 °C
View Scheme
参考文献
Sun, Zhenhua; Ahmed, Shahadat; McLaughlin, Larry W.
Journal of Organic Chemistry, 2006 , vol. 71, # 7 p. 2922 - 2925
反应条件
1: 85 percent / pyridine / 12 h / 20 °C
2: 64 percent / HBF4; NaNO2 / H2O / 2 h / -5 °C
3: 88 percent / H2SO4 / methanol; H2O / 12 h / 25 °C
4: H2SO4; NaNO2 / H2O / 2 h / -5 °C
View Scheme
参考文献
Sun, Zhenhua; Ahmed, Shahadat; McLaughlin, Larry W.
Journal of Organic Chemistry, 2006 , vol. 71, # 7 p. 2922 - 2925
