sodium hydroxide 1.) reflux, 2 h, 2.) ethanol, reflux, 45 min;

hydrogenchloride; n-butyllithium in tetrahydrofuran; hexane

in water; N,N-dimethyl-formamide

hydrogenchloride; sodium hydroxide

1: 1.) n-butyllithium / 1.) hexane, THF, from -78 to -50 deg C, 2.) hexane, THF, from -78 to -4 deg C, 45 min 2: 52 percent / 3 N hydrochloric acid / diethyl ether 3: 95 percent / 1 N aq. sodium hydroxide / 1.) reflux, 2 h, 2.) ethanol, reflux, 45 min View Scheme

1: 1.) n-butyllithium / 1.) hexane, THF, from -78 to -50 deg C, 2.) hexane, THF, from -78 to -4 deg C, 45 min 2: 52 percent / 3 N hydrochloric acid / diethyl ether 3: 95 percent / 1 N aq. sodium hydroxide / 1.) reflux, 2 h, 2.) ethanol, reflux, 45 min View Scheme