1-(1-甲基-1H-咪唑-2-基)乙酮合成路线 （共 7 条）
反应条件
1: 1-methyl-1H-imidazole With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; 0.75 h; Inert atmosphere;
2: ethyl acetate in tetrahydrofuran; hexane
T=-78 - 20°C; 3 h; Inert atmosphere;
参考文献
Willemsen, Jorgen S.; Megens, Rik P.; Roelfes, Gerard; Van Hest, Jan C. M.; Rutjes, Floris P. J. T.
European Journal of Organic Chemistry, 2014 , vol. 2014, # 14 p. 2892 - 2898
反应条件
1: 1-methyl-1H-imidazole With n-butyllithium in tetrahydrofuran; hexane
T=0°C; 0.416667 h; Inert atmosphere;
2: 4-acetylmorpholine in tetrahydrofuran; hexane
T=-78°C; 1 h; Inert atmosphere;
参考文献
Wang, Jocelyn; Benedetti, Erica; Bethge, Lucas; Vonhoff, Stefan; Klussmann, Sven; Vasseur, Jean-Jacques; Cossy, Janine; Smietana, Michael; Arseniyadis, Stellios
Angewandte Chemie - International Edition, 2013 , vol. 52, # 44 p. 11546 - 11549
Angew. Chem., 2013 , vol. 125, # 44 p. 11760 - 11763
反应条件
manganese(IV) oxide in chloroform
2 h; Heating;
参考文献
Khazan, Minoo; Hadizadeh, Farzin; Shafiee, Abbas
Journal of Heterocyclic Chemistry, 1997 , vol. 34, # 5 p. 1543 - 1547
反应条件
in diethyl ether
T=20°C; 3 h;
参考文献
Abarca-Gonzalez, Belen; Jones, R. Alan; Medio-Simon, Mercedes; Quilez-Pardo, Juan; Sepulveda-Arques, Jose; Zaballos-Garcia, Elena
Synthetic Communications, 1990 , vol. 20, # 3 p. 321 - 331
反应条件
1: 74 percent / diethyl ether; hexane / 1.) 0 deg C, 4 h, 2.) RT, 1 h
2: 85 percent / MnO2 / CHCl3 / 2 h / Heating
View Scheme
参考文献
Khazan, Minoo; Hadizadeh, Farzin; Shafiee, Abbas
Journal of Heterocyclic Chemistry, 1997 , vol. 34, # 5 p. 1543 - 1547
反应条件
potassium hydroxide in ethanol
T=23°C; 12 h;
参考文献
Myers, Michael C.; Bharadwaj, Ashwin R.; Milgram, Benjamin C.; Scheidt, Karl A.
Journal of the American Chemical Society, 2005 , vol. 127, # 42 p. 14675 - 14680
参考文献
Pfizer Inc.
Patent: US4675186 A1, 1987 ;
US 4675186 A
