1: 84.9 percent / 3.52 N HCl (in ethyl acetate) / CH2Cl2 / 1.5 h / Ambient temperature 2: 85.5 percent / TEA / ethanol / Ambient temperature 3: 88.6 percent / NaBH4 / ethanol / 72 h / Ambient temperature View Scheme

<b>Multi-step reaction with 4 steps<br /> </b>1: 62.4 percent / 3 N H₂SO₄ / H₂O / 16 h / Heating<br />2: pyridine / 0 &deg;C<br />3: aq. NaOH / methanol<br />4: 85.4 percent / diethyl ether; 1,2-dichloro-ethane / 1 h / Ambient temperature<br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: aq. NaOH / methanol<br />2: 85.4 percent / diethyl ether; 1,2-dichloro-ethane / 1 h / Ambient temperature<br /> <br /> &nbsp;

<b>Multi-step reaction with 5 steps<br /> </b>1: 45.4 percent / n-butyllithium / hexane; tetrahydrofuran / -5 &deg;C<br />2: 62.4 percent / 3 N H₂SO₄ / H₂O / 16 h / Heating<br />3: pyridine / 0 &deg;C<br />4: aq. NaOH / methanol<br />5: 85.4 percent / diethyl ether; 1,2-dichloro-ethane / 1 h / Ambient temperature<br /> <br /> &nbsp;