2-乙酰氧基-3-(十八烷氧基)丙基2-(三甲基铵基)乙基磷酸酯合成路线 （共 12 条）
反应条件
1: Et3N / toluene / 3 h / Heating
2: pyridine
3: H2, CaCO3 / 10percent Pd/C / CHCl3 / 18 h / 40 °C / 1034.3 Torr
4: 1.) Et3N, 2.) Et3N, water / 1.) diethyl ether, RT, 5 h, 2.) diethyl ether, reflux, 2 h
5: CHCl3; propan-2-ol; dimethylformamide / 12 h / 50 °C
View Scheme
参考文献
Godfroid, Jean-Jacques; Broquet, Colette; Jouquey, Simone; Lebbar, Mariya; Heymans, Francoise; et al.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 5 p. 792 - 797
反应条件
1: pyridine
2: H2, CaCO3 / 10percent Pd/C / CHCl3 / 18 h / 40 °C / 1034.3 Torr
3: 1.) Et3N, 2.) Et3N, water / 1.) diethyl ether, RT, 5 h, 2.) diethyl ether, reflux, 2 h
4: CHCl3; propan-2-ol; dimethylformamide / 12 h / 50 °C
View Scheme
参考文献
Godfroid, Jean-Jacques; Broquet, Colette; Jouquey, Simone; Lebbar, Mariya; Heymans, Francoise; et al.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 5 p. 792 - 797
反应条件
1: H2, CaCO3 / 10percent Pd/C / CHCl3 / 18 h / 40 °C / 1034.3 Torr
2: 1.) Et3N, 2.) Et3N, water / 1.) diethyl ether, RT, 5 h, 2.) diethyl ether, reflux, 2 h
3: CHCl3; propan-2-ol; dimethylformamide / 12 h / 50 °C
View Scheme
参考文献
Godfroid, Jean-Jacques; Broquet, Colette; Jouquey, Simone; Lebbar, Mariya; Heymans, Francoise; et al.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 5 p. 792 - 797
反应条件
1: Et3N / trichloroethene / 4 h
2: 1M Na2CO3
3: CHCl3; dimethylformamide; propan-2-ol; H2O / 12 h / 50 °C
4: H2 / Pd/C / ethanol / 5 h / 50 °C
5: Et3N / CHCl3
View Scheme
参考文献
Marx; Wiley
Tetrahedron Letters, 1985 , vol. 26, # 11 p. 1379 - 1380
反应条件
1: K2CO3 / methanol / 4 h / Ambient temperature
2: Et3N / trichloroethene / 4 h
3: 1M Na2CO3
4: CHCl3; dimethylformamide; propan-2-ol; H2O / 12 h / 50 °C
5: H2 / Pd/C / ethanol / 5 h / 50 °C
6: Et3N / CHCl3
View Scheme
参考文献
Marx; Wiley
Tetrahedron Letters, 1985 , vol. 26, # 11 p. 1379 - 1380
反应条件
1: 1M Na2CO3
2: CHCl3; dimethylformamide; propan-2-ol; H2O / 12 h / 50 °C
3: H2 / Pd/C / ethanol / 5 h / 50 °C
4: Et3N / CHCl3
View Scheme
参考文献
Marx; Wiley
Tetrahedron Letters, 1985 , vol. 26, # 11 p. 1379 - 1380
反应条件
1: H2 / Pd/C / ethanol / 5 h / 50 °C
2: Et3N / CHCl3
View Scheme
参考文献
Marx; Wiley
Tetrahedron Letters, 1985 , vol. 26, # 11 p. 1379 - 1380
反应条件
1: CHCl3; dimethylformamide; propan-2-ol; H2O / 12 h / 50 °C
2: H2 / Pd/C / ethanol / 5 h / 50 °C
3: Et3N / CHCl3
View Scheme
参考文献
Marx; Wiley
Tetrahedron Letters, 1985 , vol. 26, # 11 p. 1379 - 1380
反应条件
1: 1.) Et3N, 2.) Et3N, water / 1.) diethyl ether, RT, 5 h, 2.) diethyl ether, reflux, 2 h
2: CHCl3; propan-2-ol; dimethylformamide / 12 h / 50 °C
View Scheme
参考文献
Godfroid, Jean-Jacques; Broquet, Colette; Jouquey, Simone; Lebbar, Mariya; Heymans, Francoise; et al.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 5 p. 792 - 797
反应条件
in chloroform; N,N-dimethyl-formamide; isopropyl alcohol
T=50°C; 12 h;
参考文献
Godfroid, Jean-Jacques; Broquet, Colette; Jouquey, Simone; Lebbar, Mariya; Heymans, Francoise; et al.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 5 p. 792 - 797
