caesium acetate in N,N-dimethyl-formamide T=120°C; 24 h;

tetrabutyl ammonium fluoride; palladium diacetate; acetic acid; silver(l) oxide in tetrahydrofuran; ethanol T=20°C; Inert atmosphere; regioselective reaction;

1.1: NaH / dimethylformamide / 0 °C 1.2: 92 percent / dimethylformamide / 0 - 20 °C 2.1: 81 percent / cesium acetate; palladium acetate; triphenylphosphine / N,N-dimethyl-acetamide / 24 h / 125 °C View Scheme