4-氯-3-甲氧基苯甲酸合成路线 （共 14 条）
反应条件
potassium permanganate in pyridine; water 1.) 50 deg C, 24 h, 2.) RT, 13 h;
参考文献
Claudi, Francesco; Giorgioni, Gianfabio; Stefano, Antonio Di; Abbracchio, Maria Pia; Paoletti, Anna Maria; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 23 p. 4408 - 4414
反应条件
1: With n-butyllithium; potassium tert-butylate in tetrahydrofuran T=-78 - -50°C; 2 h; 2: With 1,2,2-trichloro-1,1,2-trichloro-ethane in tetrahydrofuran T=-50°C; 0.5 h; 3: With hydrogenchloride T=20°C;
参考文献
Nguyen, Thi-Huu; Chau, Nguyet Trang Thanh; Castanet, Anne-Sophie; Nguyen, Kim Phi Phung; Mortier, Jacques
Journal of Organic Chemistry, 2007 , vol. 72, # 9 p. 3419 - 3429
反应条件
1: 80 percent / K2CO3 / acetone 2: 92 percent / KMnO4 / pyridine; H2O / 1.) 50 deg C, 24 h, 2.) RT, 13 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 23 p. 4408 - 4414
反应条件
sodium hypochlorite; potassium carbonate in acetone
参考文献
Journal of Heterocyclic Chemistry, , vol. 20, # 1 p. 55 - 59
反应条件
1: LiAlH4 / tetrahydrofuran 2: PBr3 3: 76 percent / benzene / Heating View Scheme
参考文献
Akita; Matsukura; Oishi
Tetrahedron Letters, 1986 , vol. 27, # 45 p. 5397 - 5400
反应条件
1: SOCl2 / benzene / 1 h / Heating 2: 2.) SOCl2 / 1.) CH2Cl2, RT, overnight, 2.) Et2O, RT, 1 h 3: 1.) 1.6N n-butyllithium, 2.) p-toluenesulfonylazide / 1.) ether, hexane, -40 deg C, 45 min, 2.) -40 deg C, 4 h 4: 79 percent / hexadecyl tributylphosphonium bromide, NaBH4 / toluene; H2O / 24 h / 80 °C 5: 52 percent / 48percent HBr / 18 h / Heating View Scheme
参考文献
Melikian; Boigegrain; Kan; Soubrie
European Journal of Medicinal Chemistry, 1990 , vol. 25, # 3 p. 267 - 270
反应条件
1: 94 percent / BH3 / tetrahydrofuran / 2 h / Heating 2: 73.7 percent / MnO2 / benzene / 9 h / Heating View Scheme
参考文献
Pfeiffer; Wilson; Weinstock; Kuo; Chambers; Holden; Hahn; Wardell Jr.; Tobia; Setler; Sarau
Journal of Medicinal Chemistry, 1982 , vol. 25, # 4 p. 352 - 358
参考文献
Portola Pharmaceuticals, Inc.
Patent: US6906063 B2, 2005 ;
反应条件
in tetrahydrofuran; water
参考文献
Sterling Winthrop Inc.
Patent: US5554620 A1, 1996 ;
