4-氯-3-甲氧基苯甲酸合成路线 （共 14 条）
反应条件
acetyl chloride T=0 - 20°C;
参考文献
El-Gamal, Mohammed I.; Choi, Hong Seok; Yoo, Kyung Ho; Baek, Daejin; Oh, Chang-Hyun
Chemical Biology and Drug Design, 2013 , vol. 82, # 3 p. 336 - 347
反应条件
1: LiAlH4 / tetrahydrofuran
2: PBr3
View Scheme
参考文献
Akita; Matsukura; Oishi
Tetrahedron Letters, 1986 , vol. 27, # 45 p. 5397 - 5400
反应条件
1: thionyl chloride / 4 h / Heating
2: 1.) CdCl2, 2.) aq. NH4Cl / 1.) ether, from -5 deg C to reflux, 1 h, 2.) benzene, reflux, 1 h
View Scheme
参考文献
Hartmann; Heindl; Schonenberger
Journal of Medicinal Chemistry, 1984 , vol. 27, # 5 p. 577 - 585
参考文献
Bhatia, Pramila A.; Daanen, Jerome F.; Hakeem, Ahmed A.; Kolasa, Teodozyj; Matulenko, Mark A.; Mortell, Kathleen H.; Patel, Meena V.; Stewart, Andrew O.; Wang, Xueqing; Xia, Zhiren; Zhang, Henry Q.
Patent: US2004/29887 A1, 2004 ;
