(E)-3-O-甲基恩他卡朋合成路线 （共 7 条）
反应条件
sodium hydroxide in methanol T=20°C; 16 h;
参考文献
Dipharma Francis S.r.l.
Patent: EP1935873 A1, 2008 ;
Location in patent: Page/Page column 5 ;
反应条件
nitric acid; sodium nitrite in dichloromethane T=20°C; 2 h; TimeConcentration;
参考文献
SUNSHINE LAKE PHARMA CO., LTD.; ZHOU, Dongsheng; LIU, Liu; MAO, Bin; LIU, Yun
Patent: WO2013/149566 A1, 2013 ;
Location in patent: Paragraph 0042 ;
反应条件
piperidine; acetic acid in toluene T=105 - 110°C; 15 h; Heating / reflux;
参考文献
WO2005/63693 A1, ;
Page/Page column 7-8 ;
反应条件
nitric acid in acetic acid T=20°C; 3 h; Product distribution / selectivity;
参考文献
WO2006/64296 A1, ;
Page/Page column 6-7 ;
反应条件
1: acetic acid; diethylamine / toluene / Reflux 2: nitric acid View Scheme
参考文献
Synthetic Communications, , vol. 42, # 9 p. 1359 - 1366
反应条件
1: acetic acid; diethylamine / toluene / Reflux 2: nitric acid View Scheme
参考文献
Synthetic Communications, , vol. 42, # 9 p. 1359 - 1366
反应条件
1: With AlCl3, aluminium chloride; triethylamine in dichloromethane T=0 - 5°C; 3 - 4 h; Heating / reflux; 2: With hydrogenchloride in dichloromethane T=0 - 20°C; 0.5 h;
参考文献
Dipharma Francis S.r.l.
Patent: EP1935873 A1, 2008 ;
Location in patent: Page/Page column 6 ;
