4-苄基-5-(3,3,4,4,5,5,6,6,7,7,8,8,8-十三氟辛基)-1,3-恶唑烷-2-酮合成路线 （共 21 条）
→
857637-92-44-苄基-5-(3,3,4,4,5,5,6,6,7,7,8,8,8-十三氟辛基)-1,3-恶唑烷-2-酮
反应条件
sodium hydride in tetrahydrofuran
参考文献
Hein, Jason E.; Geary, Laina M.; Jaworski, Ashley A.; Hultin, Philip G.
Journal of Organic Chemistry, 2005 , vol. 70, # 24 p. 9940 - 9946
→
857637-92-44-苄基-5-(3,3,4,4,5,5,6,6,7,7,8,8,8-十三氟辛基)-1,3-恶唑烷-2-酮
反应条件
sodium hydride in tetrahydrofuran
T=20°C; 12 h;
参考文献
Hein, Jason E.; Geary, Laina M.; Jaworski, Ashley A.; Hultin, Philip G.
Journal of Organic Chemistry, 2005 , vol. 70, # 24 p. 9940 - 9946
→
857637-92-44-苄基-5-(3,3,4,4,5,5,6,6,7,7,8,8,8-十三氟辛基)-1,3-恶唑烷-2-酮+
反应条件
lithium hydroxide; dihydrogen peroxide in tetrahydrofuran; water
T=0°C; 3 h;
参考文献
Hein, Jason E.; Zimmerman, Jake; Sibi, Mukund P.; Hultin, Philip G.
Organic Letters, 2005 , vol. 7, # 13 p. 2755 - 2758
→
857637-92-44-苄基-5-(3,3,4,4,5,5,6,6,7,7,8,8,8-十三氟辛基)-1,3-恶唑烷-2-酮
反应条件
1: ZrCl4; tributyltin hydride; triethylborane / O2 / CH2Cl2; tetrahydrofuran / 2 h / 0 °C
2: 88 percent / H2O2; LiOH*H2O / tetrahydrofuran; H2O / 3 h / 0 °C
View Scheme
参考文献
Hein, Jason E.; Zimmerman, Jake; Sibi, Mukund P.; Hultin, Philip G.
Organic Letters, 2005 , vol. 7, # 13 p. 2755 - 2758
→
857637-92-44-苄基-5-(3,3,4,4,5,5,6,6,7,7,8,8,8-十三氟辛基)-1,3-恶唑烷-2-酮
反应条件
1: Yb(OTf)3; tributyltin hydride; triethylborane / O2 / CH2Cl2; tetrahydrofuran / -78 °C
2: H2O2; LiOH*H2O / tetrahydrofuran; H2O / 0 °C
View Scheme
参考文献
Hein, Jason E.; Zimmerman, Jake; Sibi, Mukund P.; Hultin, Philip G.
Organic Letters, 2005 , vol. 7, # 13 p. 2755 - 2758
→
857637-92-44-苄基-5-(3,3,4,4,5,5,6,6,7,7,8,8,8-十三氟辛基)-1,3-恶唑烷-2-酮
反应条件
1: Yb(OTf)3; tributyltin hydride; triethylborane / O2 / CH2Cl2; tetrahydrofuran / -78 °C
2: H2O2; LiOH*H2O / tetrahydrofuran; H2O / 0 °C
View Scheme
参考文献
Hein, Jason E.; Zimmerman, Jake; Sibi, Mukund P.; Hultin, Philip G.
Organic Letters, 2005 , vol. 7, # 13 p. 2755 - 2758
→
857637-92-44-苄基-5-(3,3,4,4,5,5,6,6,7,7,8,8,8-十三氟辛基)-1,3-恶唑烷-2-酮+
反应条件
lithium hydroxide; dihydrogen peroxide in tetrahydrofuran; water
T=0°C;
参考文献
Hein, Jason E.; Zimmerman, Jake; Sibi, Mukund P.; Hultin, Philip G.
Organic Letters, 2005 , vol. 7, # 13 p. 2755 - 2758
→
857637-92-44-苄基-5-(3,3,4,4,5,5,6,6,7,7,8,8,8-十三氟辛基)-1,3-恶唑烷-2-酮
反应条件
lithium hydroxide; dihydrogen peroxide in tetrahydrofuran; water
T=0°C;
参考文献
Hein, Jason E.; Zimmerman, Jake; Sibi, Mukund P.; Hultin, Philip G.
Organic Letters, 2005 , vol. 7, # 13 p. 2755 - 2758
→
857637-92-44-苄基-5-(3,3,4,4,5,5,6,6,7,7,8,8,8-十三氟辛基)-1,3-恶唑烷-2-酮
反应条件
1: iBuCOCl
2: LiAlH(OtBu)3
3: NaH / tetrahydrofuran
View Scheme
参考文献
Hein, Jason E.; Zimmerman, Jake; Sibi, Mukund P.; Hultin, Philip G.
Organic Letters, 2005 , vol. 7, # 13 p. 2755 - 2758
→
857637-92-44-苄基-5-(3,3,4,4,5,5,6,6,7,7,8,8,8-十三氟辛基)-1,3-恶唑烷-2-酮
反应条件
1: LiAlH(OtBu)3
2: NaH / tetrahydrofuran
View Scheme
参考文献
Hein, Jason E.; Zimmerman, Jake; Sibi, Mukund P.; Hultin, Philip G.
Organic Letters, 2005 , vol. 7, # 13 p. 2755 - 2758
