4-苄基-5-(3,3,4,4,5,5,6,6,7,7,8,8,8-十三氟辛基)-1,3-恶唑烷-2-酮合成路线 （共 21 条）
→
857637-92-44-苄基-5-(3,3,4,4,5,5,6,6,7,7,8,8,8-十三氟辛基)-1,3-恶唑烷-2-酮
反应条件
1: LiAlH(OtBu)3
2: NaH / tetrahydrofuran
View Scheme
参考文献
Hein, Jason E.; Zimmerman, Jake; Sibi, Mukund P.; Hultin, Philip G.
Organic Letters, 2005 , vol. 7, # 13 p. 2755 - 2758
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857637-92-44-苄基-5-(3,3,4,4,5,5,6,6,7,7,8,8,8-十三氟辛基)-1,3-恶唑烷-2-酮
反应条件
1: iBuCOCl
2: LiAlH(OtBu)3
3: NaH / tetrahydrofuran
View Scheme
参考文献
Hein, Jason E.; Zimmerman, Jake; Sibi, Mukund P.; Hultin, Philip G.
Organic Letters, 2005 , vol. 7, # 13 p. 2755 - 2758
→
857637-92-44-苄基-5-(3,3,4,4,5,5,6,6,7,7,8,8,8-十三氟辛基)-1,3-恶唑烷-2-酮
反应条件
1.1: Mg / diethyl ether
1.2: 15 percent / diethyl ether / 4 h
2.1: 97 percent / LiAlH(OtBu)3 / ethanol / -78 - 20 °C
3.1: NaH / tetrahydrofuran
View Scheme
参考文献
Hein, Jason E.; Geary, Laina M.; Jaworski, Ashley A.; Hultin, Philip G.
Journal of Organic Chemistry, 2005 , vol. 70, # 24 p. 9940 - 9946
→
857637-92-44-苄基-5-(3,3,4,4,5,5,6,6,7,7,8,8,8-十三氟辛基)-1,3-恶唑烷-2-酮
反应条件
1.1: 70 percent / triethylamine / tetrahydrofuran; hexane / 2 h / 0 °C
2.1: t-BuLi / diethyl ether; hexane / -78 - -60 °C
2.2: diethyl ether; hexane / -78 - 20 °C
3.1: 99 percent / LiAlH(OtBu)3 / ethanol / -78 - 20 °C
4.1: NaH / tetrahydrofuran
View Scheme
参考文献
Hein, Jason E.; Geary, Laina M.; Jaworski, Ashley A.; Hultin, Philip G.
Journal of Organic Chemistry, 2005 , vol. 70, # 24 p. 9940 - 9946
→
857637-92-44-苄基-5-(3,3,4,4,5,5,6,6,7,7,8,8,8-十三氟辛基)-1,3-恶唑烷-2-酮
反应条件
sodium hydride in tetrahydrofuran
参考文献
Hein, Jason E.; Geary, Laina M.; Jaworski, Ashley A.; Hultin, Philip G.
Journal of Organic Chemistry, 2005 , vol. 70, # 24 p. 9940 - 9946
→
857637-92-44-苄基-5-(3,3,4,4,5,5,6,6,7,7,8,8,8-十三氟辛基)-1,3-恶唑烷-2-酮
反应条件
1: 99 percent / LiAlH(OtBu)3 / ethanol / -78 - 20 °C
2: NaH / tetrahydrofuran
View Scheme
参考文献
Hein, Jason E.; Geary, Laina M.; Jaworski, Ashley A.; Hultin, Philip G.
Journal of Organic Chemistry, 2005 , vol. 70, # 24 p. 9940 - 9946
→
857637-92-44-苄基-5-(3,3,4,4,5,5,6,6,7,7,8,8,8-十三氟辛基)-1,3-恶唑烷-2-酮
反应条件
1: 97 percent / LiAlH(OtBu)3 / ethanol / -78 - 20 °C
2: NaH / tetrahydrofuran
View Scheme
参考文献
Hein, Jason E.; Geary, Laina M.; Jaworski, Ashley A.; Hultin, Philip G.
Journal of Organic Chemistry, 2005 , vol. 70, # 24 p. 9940 - 9946
→
857637-92-44-苄基-5-(3,3,4,4,5,5,6,6,7,7,8,8,8-十三氟辛基)-1,3-恶唑烷-2-酮
反应条件
1.1: Mg / diethyl ether
1.2: 15 percent / diethyl ether / 4 h
2.1: 97 percent / LiAlH(OtBu)3 / ethanol / -78 - 20 °C
3.1: NaH / tetrahydrofuran
View Scheme
参考文献
Hein, Jason E.; Geary, Laina M.; Jaworski, Ashley A.; Hultin, Philip G.
Journal of Organic Chemistry, 2005 , vol. 70, # 24 p. 9940 - 9946
→
857637-92-44-苄基-5-(3,3,4,4,5,5,6,6,7,7,8,8,8-十三氟辛基)-1,3-恶唑烷-2-酮
反应条件
1.1: t-BuLi / diethyl ether; hexane / -78 - -60 °C
1.2: diethyl ether; hexane / -78 - 20 °C
2.1: 99 percent / LiAlH(OtBu)3 / ethanol / -78 - 20 °C
3.1: NaH / tetrahydrofuran
View Scheme
参考文献
Hein, Jason E.; Geary, Laina M.; Jaworski, Ashley A.; Hultin, Philip G.
Journal of Organic Chemistry, 2005 , vol. 70, # 24 p. 9940 - 9946
→
857637-92-44-苄基-5-(3,3,4,4,5,5,6,6,7,7,8,8,8-十三氟辛基)-1,3-恶唑烷-2-酮
反应条件
1.1: t-BuLi / diethyl ether; hexane / -78 - -60 °C
1.2: diethyl ether; hexane / -78 - 20 °C
2.1: 97 percent / LiAlH(OtBu)3 / ethanol / -78 - 20 °C
3.1: NaH / tetrahydrofuran
View Scheme
参考文献
Hein, Jason E.; Geary, Laina M.; Jaworski, Ashley A.; Hultin, Philip G.
Journal of Organic Chemistry, 2005 , vol. 70, # 24 p. 9940 - 9946
