反应条件
1: hydrogenchloride / water; dichloromethane / 1.5 h / 0 - 10 °C 2: water; dichloromethane / 0 - 20 °C 3: hydrogenchloride / water / 20 - 60 °C 4: thionyl chloride / 0 °C / |Reflux 5: ethanol; acetone / 0.5 h / 40 °C / |Resolution of racemate 6: potassium carbonate / water; ethyl acetate / 1 h / 15 - 20 °C View Scheme
参考文献
LUNDBECK PHARMACEUTICALS ITALY S.P.A.; Stivanello, Mariano; Huber, Florian Anton Martin; Ricci, Antonio
Patent: US2014/88310 A1, 2014 ;
