1: With sodium hydroxide in methanol T=20°C; Inert atmosphere; 2: With hydrogenchloride; water

1: 4-methoxyphenyl magnesium bromide in tetrahydrofuran T=-20°C; 0.166667 h; 2: bromobenzoic acid ethyl ester With para-fluorostyrene; tetra-(n-butyl)ammonium iodide; cobalt(II) 2,4-pentanedionate in tetrahydrofuran; ethylene glycol dimethyl ether T=80°C; 0.25 h;

(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in tetrahydrofuran T=60°C; Negishi coupling reaction; 2 h; Inert atmosphere;

1: 4-methoxyphenyl magnesium bromide in tetrahydrofuran T=-20°C; 0.166667 h; 2: ethyl 2-fluoro-benzoate With N,N'-dimethyl-N,N'-propyleneurea; para-fluorostyrene; tetra-(n-butyl)ammonium iodide; cobalt(II) 2,4-pentanedionate in tetrahydrofuran; ethylene glycol dimethyl ether T=80°C; 0.25 h;

manganese; cobalt (II) bromide; triphenylphosphine; trifluoroacetic acid in pyridine; N,N-dimethyl-formamide T=50°C;

1: 1-bromo-4-methoxy-benzene With diisobutyl-aluminum chloride; diisobutylaluminium hydride; magnesium; lithium chloride in tetrahydrofuran; n-heptane T=25°C; 3 h; 2: bromobenzoic acid ethyl ester With PEPPSITM-IPr in tetrahydrofuran T=25°C; 1 h;

bis-triphenylphosphine-palladium(II) chloride; sodium carbonate in tetrahydrofuran; water T=60°C; Inert atmosphere;