N,N-二甲基-1-[三(1-甲基乙基)甲硅烷基]-1H-吡咯并[2,3-b]吡啶-3-甲胺合成路线 （共 5 条）
反应条件
1: 3-(N,N-dimethylaminomethyl)-1H-pyrrolo[2,3-b]pyridine With sodium hydride in tetrahydrofuran
T=0 - 20°C; 1 h;
2: triisopropylsilyl chloride in tetrahydrofuran
T=0 - 20°C;
参考文献
Plexxikon, Inc.
Patent: US2007/49615 A1, 2007 ;
Location in patent: Page/Page column 66 ;
反应条件
sodium hydride in N,N-dimethyl-formamide
T=20°C; 12 h;
参考文献
PLEXXIKON, INC.
Patent: WO2006/9755 A2, 2006 ;
Location in patent: Page/Page column 290 ;
WO 2006/009755 A2
反应条件
1: With tert.-butyl lithium in hexanes; diethyl ether
T=-78 - 20°C;
2: With ethylene dibromide in hexanes; diethyl ether
T=-78 - 20°C; 2 - 3 h;
3: With water in hexanes; diethyl ether
参考文献
Plexxikon, Inc.
Patent: US2007/49615 A1, 2007 ;
Location in patent: Page/Page column 66 ;
反应条件
isopropyloxycarbonylchloride in toluene
T=20°C; 2 h;
参考文献
Plexxikon, Inc.
Patent: US2007/49615 A1, 2007 ;
Location in patent: Page/Page column 75 ;
反应条件
isopropyloxycarbonylchloride in toluene
T=20°C; 2 h;
参考文献
PLEXXIKON, INC.
Patent: WO2006/9755 A2, 2006 ;
Location in patent: Page/Page column 291 ;
WO 2006/009755 A2
