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结构式
乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
858120-58-8
合成路线
（共 7 条）
858120-57-7
→
反应条件
858120-58-8
反应条件
1: With toluene-4-sulfonic acid in toluene 6 h; Reflux; 2: With sodium carbonate in toluene
参考文献
NOVARTIS AG; Bock, Mark Gary; Gaul, Christoph; Gummadi, Venkateshwar Rao; Moebitz, Henrik; Sengupta, Saumitra
Patent: US2014/45872 A1, 2014 ;
Location in patent: Paragraph 0985 ;
1414864-54-2
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反应条件
858120-58-8
反应条件
ammonium chloride; acetic acid in water 4 h; Reflux;
参考文献
Galli, Ubaldina; Mesenzani, Ornella; Coppo, Camilla; Sorba, Giovanni; Canonico, Pier Luigi; Tron, Gian Cesare; Genazzani, Armando A.
European Journal of Medicinal Chemistry, 2012 , vol. 55, p. 58 - 66,9
37831-62-2
4-氯烟酸乙酯盐酸盐
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反应条件
858120-58-8
反应条件
1: N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium(0); copper(l) iodide / 8 h / 80 °C / |Inert atmosphere 2: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 - 20 °C / |Inert atmosphere 3: hydrogen; palladium / ethyl acetate / 0.67 h / 20 °C 4: ammonium chloride; acetic acid / water / 4 h / |Reflux View Scheme
参考文献
Galli, Ubaldina; Mesenzani, Ornella; Coppo, Camilla; Sorba, Giovanni; Canonico, Pier Luigi; Tron, Gian Cesare; Genazzani, Armando A.
European Journal of Medicinal Chemistry, 2012 , vol. 55, p. 58 - 66,9
1395410-78-2
→
反应条件
858120-58-8
反应条件
1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 - 20 °C / |Inert atmosphere 2: hydrogen; palladium / ethyl acetate / 0.67 h / 20 °C 3: ammonium chloride; acetic acid / water / 4 h / |Reflux View Scheme
参考文献
Galli, Ubaldina; Mesenzani, Ornella; Coppo, Camilla; Sorba, Giovanni; Canonico, Pier Luigi; Tron, Gian Cesare; Genazzani, Armando A.
European Journal of Medicinal Chemistry, 2012 , vol. 55, p. 58 - 66,9
6790-32-5
龙胆定碱
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反应条件
858120-58-8
反应条件
1.1: tetrahydrofuran / 48 h / Reflux 1.2: 0 °C 2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 1 h / 0 - 20 °C 3.1: toluene-4-sulfonic acid / toluene / 6 h / Reflux View Scheme
参考文献
NOVARTIS AG; BOCK, Mark G.; GAUL, Christoph; GUMMADI, Venkateshwar Rao; MOEBITZ, Henrik; SENGUPTA, Saumitra
Patent: WO2012/35078 A1, 2012 ;
WO 2012/035078 A1
124870-33-3
2-(3-氰基吡啶-4-基)乙酸甲酯
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反应条件
858120-58-8
反应条件
1.1: ethanol; sodium tetrahydroborate / 4 h / 0 °C 2.1: hydrogenchloride / water / Reflux 3.1: tetrahydrofuran / 48 h / Reflux 3.2: 0 °C 4.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 1 h / 0 - 20 °C 5.1: toluene-4-sulfonic acid / toluene / 6 h / Reflux View Scheme
参考文献
NOVARTIS AG; BOCK, Mark G.; GAUL, Christoph; GUMMADI, Venkateshwar Rao; MOEBITZ, Henrik; SENGUPTA, Saumitra
Patent: WO2012/35078 A1, 2012 ;
WO 2012/035078 A1
5444-01-9
3-氰基-4-甲基吡啶
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反应条件
858120-58-8
反应条件
1.1: lithium hexamethyldisilazane / tetrahydrofuran / 4 h / -78 - 0 °C 2.1: ethanol; sodium tetrahydroborate / 4 h / 0 °C 3.1: hydrogenchloride / water / Reflux 4.1: tetrahydrofuran / 48 h / Reflux 4.2: 0 °C 5.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 1 h / 0 - 20 °C 6.1: toluene-4-sulfonic acid / toluene / 6 h / Reflux View Scheme
参考文献
NOVARTIS AG; BOCK, Mark G.; GAUL, Christoph; GUMMADI, Venkateshwar Rao; MOEBITZ, Henrik; SENGUPTA, Saumitra
Patent: WO2012/35078 A1, 2012 ;
WO 2012/035078 A1
