4,4'',5',6'-四羟基-1,1':4',1''-三联苯-2',3'-二基二(苯乙酸酯)合成路线 （共 19 条）
反应条件
hydrogenchloride in dichloromethane
T=20°C; 30 h;
参考文献
Ye, Yue Qi; Koshino, Hiroyuki; Onose, Jun-Ichi; Yoshikawa, Kunie; Abe, Naoki; Takahashi, Shunya
Organic Letters, 2007 , vol. 9, # 21 p. 4131 - 4134
反应条件
AlCl3, aluminium chloride; ethane-1,2-dithiol in nitromethane
T=-20°C; 0.5 h;
参考文献
Fujiwara, Kenshu; Sato, Takuto; Sano, Yusuke; Norikura, Toshio; Katoono, Ryo; Suzuki, Takanori; Matsue, Hajime
Journal of Organic Chemistry, 2012 , vol. 77, # 11 p. 5161 - 5166
反应条件
1.1: n-BuLi / tetrahydrofuran; hexane / 1.5 h / 0 °C
1.2: isopropyl borate / tetrahydrofuran; hexane / 0.83 h / 0 °C
1.3: 87 percent / AcOH; aq. H2O2 / tetrahydrofuran; hexane / 16 h / 0 - 20 °C
2.1: 89 percent / pyridine / 2.5 h / 0 °C
3.1: 96 percent / KBr; K3PO4 / (Ph3P)4Pd / dioxane / 26 h / 100 °C
4.1: 95 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone; p-TsOH*H2O / dioxane / 2.5 h / 50 °C
5.1: sodium dithionite / ethyl acetate; methanol; H2O / 4 h / 20 °C
6.1: n-BuLi / tetrahydrofuran; hexane / 0.33 h / -78 °C
6.2: 88.8 mg / tetrahydrofuran; hexane / 1.5 h / -78 - 0 °C
7.1: 90 percent / benzene / 36 h / 80 °C
8.1: 92 percent / methanolic HCl / CH2Cl2 / 30 h / 20 °C
View Scheme
参考文献
Ye, Yue Qi; Koshino, Hiroyuki; Onose, Jun-Ichi; Yoshikawa, Kunie; Abe, Naoki; Takahashi, Shunya
Organic Letters, 2007 , vol. 9, # 21 p. 4131 - 4134
反应条件
1.1: 89 percent / pyridine / 2.5 h / 0 °C
2.1: 96 percent / KBr; K3PO4 / (Ph3P)4Pd / dioxane / 26 h / 100 °C
3.1: 95 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone; p-TsOH*H2O / dioxane / 2.5 h / 50 °C
4.1: sodium dithionite / ethyl acetate; methanol; H2O / 4 h / 20 °C
5.1: n-BuLi / tetrahydrofuran; hexane / 0.33 h / -78 °C
5.2: 88.8 mg / tetrahydrofuran; hexane / 1.5 h / -78 - 0 °C
6.1: 90 percent / benzene / 36 h / 80 °C
7.1: 92 percent / methanolic HCl / CH2Cl2 / 30 h / 20 °C
View Scheme
参考文献
Ye, Yue Qi; Koshino, Hiroyuki; Onose, Jun-Ichi; Yoshikawa, Kunie; Abe, Naoki; Takahashi, Shunya
Organic Letters, 2007 , vol. 9, # 21 p. 4131 - 4134
反应条件
1.1: 96 percent / KBr; K3PO4 / (Ph3P)4Pd / dioxane / 26 h / 100 °C
2.1: 95 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone; p-TsOH*H2O / dioxane / 2.5 h / 50 °C
3.1: sodium dithionite / ethyl acetate; methanol; H2O / 4 h / 20 °C
4.1: n-BuLi / tetrahydrofuran; hexane / 0.33 h / -78 °C
4.2: 88.8 mg / tetrahydrofuran; hexane / 1.5 h / -78 - 0 °C
5.1: 90 percent / benzene / 36 h / 80 °C
6.1: 92 percent / methanolic HCl / CH2Cl2 / 30 h / 20 °C
View Scheme
参考文献
Ye, Yue Qi; Koshino, Hiroyuki; Onose, Jun-Ichi; Yoshikawa, Kunie; Abe, Naoki; Takahashi, Shunya
Organic Letters, 2007 , vol. 9, # 21 p. 4131 - 4134
反应条件
1.1: NaH / dimethylformamide / 0.5 h / 0 °C
1.2: 87 percent / dimethylformamide / 13 h / 0 - 20 °C
2.1: n-BuLi / tetrahydrofuran; hexane / 1.5 h / 0 °C
2.2: isopropyl borate / tetrahydrofuran; hexane / 0.83 h / 0 °C
2.3: 87 percent / AcOH; aq. H2O2 / tetrahydrofuran; hexane / 16 h / 0 - 20 °C
3.1: 89 percent / pyridine / 2.5 h / 0 °C
4.1: 96 percent / KBr; K3PO4 / (Ph3P)4Pd / dioxane / 26 h / 100 °C
5.1: 95 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone; p-TsOH*H2O / dioxane / 2.5 h / 50 °C
6.1: sodium dithionite / ethyl acetate; methanol; H2O / 4 h / 20 °C
7.1: n-BuLi / tetrahydrofuran; hexane / 0.33 h / -78 °C
7.2: 88.8 mg / tetrahydrofuran; hexane / 1.5 h / -78 - 0 °C
8.1: 90 percent / benzene / 36 h / 80 °C
9.1: 92 percent / methanolic HCl / CH2Cl2 / 30 h / 20 °C
View Scheme
参考文献
Ye, Yue Qi; Koshino, Hiroyuki; Onose, Jun-Ichi; Yoshikawa, Kunie; Abe, Naoki; Takahashi, Shunya
Organic Letters, 2007 , vol. 9, # 21 p. 4131 - 4134
反应条件
1.1: n-BuLi / tetrahydrofuran; hexane / 0.33 h / -78 °C
1.2: 88.8 mg / tetrahydrofuran; hexane / 1.5 h / -78 - 0 °C
2.1: 90 percent / benzene / 36 h / 80 °C
3.1: 92 percent / methanolic HCl / CH2Cl2 / 30 h / 20 °C
View Scheme
参考文献
Ye, Yue Qi; Koshino, Hiroyuki; Onose, Jun-Ichi; Yoshikawa, Kunie; Abe, Naoki; Takahashi, Shunya
Organic Letters, 2007 , vol. 9, # 21 p. 4131 - 4134
反应条件
1: 90 percent / benzene / 36 h / 80 °C
2: 92 percent / methanolic HCl / CH2Cl2 / 30 h / 20 °C
View Scheme
参考文献
Ye, Yue Qi; Koshino, Hiroyuki; Onose, Jun-Ichi; Yoshikawa, Kunie; Abe, Naoki; Takahashi, Shunya
Organic Letters, 2007 , vol. 9, # 21 p. 4131 - 4134
反应条件
1.1: 95 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone; p-TsOH*H2O / dioxane / 2.5 h / 50 °C
2.1: sodium dithionite / ethyl acetate; methanol; H2O / 4 h / 20 °C
3.1: n-BuLi / tetrahydrofuran; hexane / 0.33 h / -78 °C
3.2: 88.8 mg / tetrahydrofuran; hexane / 1.5 h / -78 - 0 °C
4.1: 90 percent / benzene / 36 h / 80 °C
5.1: 92 percent / methanolic HCl / CH2Cl2 / 30 h / 20 °C
View Scheme
参考文献
Ye, Yue Qi; Koshino, Hiroyuki; Onose, Jun-Ichi; Yoshikawa, Kunie; Abe, Naoki; Takahashi, Shunya
Organic Letters, 2007 , vol. 9, # 21 p. 4131 - 4134
反应条件
1.1: sodium dithionite / ethyl acetate; methanol; H2O / 4 h / 20 °C
2.1: n-BuLi / tetrahydrofuran; hexane / 0.33 h / -78 °C
2.2: 88.8 mg / tetrahydrofuran; hexane / 1.5 h / -78 - 0 °C
3.1: 90 percent / benzene / 36 h / 80 °C
4.1: 92 percent / methanolic HCl / CH2Cl2 / 30 h / 20 °C
View Scheme
参考文献
Ye, Yue Qi; Koshino, Hiroyuki; Onose, Jun-Ichi; Yoshikawa, Kunie; Abe, Naoki; Takahashi, Shunya
Organic Letters, 2007 , vol. 9, # 21 p. 4131 - 4134
