5-烯丙基-6-羟基-2-甲基嘧啶-4(3h)-酮合成路线 （共 4 条）
反应条件
trichlorophosphate
4 h; Heating / reflux;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2008/8895 A1, 2008 ;
Location in patent: Page/Page column 80 ;
WO 2008/008895 A1
反应条件
1: 60.6 percent / phosphoryl chloride, dimethylaniline / 7 h
2: 90.5 percent / ethanol / 6 h / Heating
View Scheme
参考文献
Melik-Ogandzhanyan, R. G.; Danagulyan, G. G.; Fagradyan, S. A.; Mirozoyan, V. S.; Okhikyan, V. M.; et al.
Pharmaceutical Chemistry Journal, 1983 , vol. 17, # 3 p. 190 - 195
Khimiko-Farmatsevticheskii Zhurnal, 1983 , vol. 17, # 3 p. 299 - 303
反应条件
1: 60.6 percent / phosphoryl chloride, dimethylaniline / 7 h
2: 74.8 percent / ethanol / 6 h / Heating
View Scheme
参考文献
Melik-Ogandzhanyan, R. G.; Danagulyan, G. G.; Fagradyan, S. A.; Mirozoyan, V. S.; Okhikyan, V. M.; et al.
Pharmaceutical Chemistry Journal, 1983 , vol. 17, # 3 p. 190 - 195
Khimiko-Farmatsevticheskii Zhurnal, 1983 , vol. 17, # 3 p. 299 - 303
反应条件
1: 60.6 percent / phosphoryl chloride, dimethylaniline / 7 h
2: 90.5 percent / ethanol / 6 h / Heating
3: 87.5 percent / bromine / CHCl3 / 3 h / Heating
View Scheme
参考文献
Melik-Ogandzhanyan, R. G.; Danagulyan, G. G.; Fagradyan, S. A.; Mirozoyan, V. S.; Okhikyan, V. M.; et al.
Pharmaceutical Chemistry Journal, 1983 , vol. 17, # 3 p. 190 - 195
Khimiko-Farmatsevticheskii Zhurnal, 1983 , vol. 17, # 3 p. 299 - 303
