5-溴-2,6-二甲基嘧啶-4-醇合成路线 （共 4 条）
反应条件
1,2,4-trimethyl benzene T=190°C;
参考文献
Yanai
Yakugaku Zasshi, 1942 , vol. 62, p. 315,333; dtsch. Ref. S. 95, 106
Chem.Abstr., 1951 , p. 5150
反应条件
trichlorophosphate
T=110°C; 3 h;
参考文献
GLAXOSMITHKLINE LLC; BROWN, Kristin, K.; CHAI, Deping; DODSON, Christopher, S.; DUFFY, Kevin, J.; SHAW, Antony, Nicholas
Patent: WO2013/96151 A1, 2013 ;
Location in patent: Page/Page column 131 ;
反应条件
1.1: trichlorophosphate / 3 h / 110 °C
2.1: toluene-4-sulfonic acid hydrazide / chloroform / 16 h / 90 °C
2.2: 1.5 h / 90 °C
View Scheme
参考文献
GLAXOSMITHKLINE LLC; BROWN, Kristin, K.; CHAI, Deping; DODSON, Christopher, S.; DUFFY, Kevin, J.; SHAW, Antony, Nicholas
Patent: WO2013/96151 A1, 2013 ;
反应条件
1: POCl3
2: methanol; NH3
View Scheme
参考文献
Ochiai; Ito
Yakugaku Zasshi, 1937 , vol. 57, p. 579,581; dtsch. Ref. S. 109, 111
Chem.Abstr., 1937 , p. 6238
