N,N-二甲基-4-((4-((4-((三甲基甲硅烷基)乙炔)苯基)乙炔)苯基)乙炔)苯胺合成路线 （共 6 条）
反应条件
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine in tetrahydrofuran
T=50°C; Sonogashira coupling; 5 h; Inert atmosphere;
参考文献
Bures, Filip; Cermakova, Hana; Kulhanek, Jiri; Ludwig, Miroslav; Kuznik, Wojciech; Kityk, Iwan V.; Mikysek, Tomas; Ruzicka, Ales
European Journal of Organic Chemistry, 2012 , # 3 p. 529 - 538
反应条件
1: N,N-dimethyl-4-{[4-[(trimethylsilyl)ethynyl]phenyl]ethynyl}aniline With potassium hydroxide in tetrahydrofuran; methanol
T=25°C; 4 h;
2: 4-(TMS-ethynyl)iodobenzene With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diethylamine in tetrahydrofuran
T=25°C; Sonogashira coupling reaction; 24 h;
参考文献
Zhi, Yong-Gang; Lai, Siu-Wai; Chan, Queenie K.-W.; Law, Yuen-Chi; Tong, Glenna S.-M.; Che, Chi-Ming
European Journal of Organic Chemistry, 2006 , # 14 p. 3125 - 3139
反应条件
1.1: KOH / methanol; tetrahydrofuran / 4 h / 25 °C
2.1: 98 percent / Pd(PPh3)2Cl2; Et2NH; CuI / tetrahydrofuran / 24 h / 25 °C
3.1: KOH / methanol; tetrahydrofuran / 4 h / 25 °C
3.2: 0.39 g / Pd(PPh3)2Cl2; CuI; NHEt2 / tetrahydrofuran / 24 h / 25 °C
View Scheme
参考文献
Zhi, Yong-Gang; Lai, Siu-Wai; Chan, Queenie K.-W.; Law, Yuen-Chi; Tong, Glenna S.-M.; Che, Chi-Ming
European Journal of Organic Chemistry, 2006 , # 14 p. 3125 - 3139
反应条件
1.1: 98 percent / Pd(PPh3)2Cl2; Et2NH; CuI / tetrahydrofuran / 24 h / 25 °C
2.1: KOH / methanol; tetrahydrofuran / 4 h / 25 °C
2.2: 0.39 g / Pd(PPh3)2Cl2; CuI; NHEt2 / tetrahydrofuran / 24 h / 25 °C
View Scheme
参考文献
Zhi, Yong-Gang; Lai, Siu-Wai; Chan, Queenie K.-W.; Law, Yuen-Chi; Tong, Glenna S.-M.; Che, Chi-Ming
European Journal of Organic Chemistry, 2006 , # 14 p. 3125 - 3139
反应条件
1.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / Inert atmosphere
2.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere
2.2: 2 h / -78 - 25 °C / Inert atmosphere
3.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / 5 h / 50 °C / Inert atmosphere
View Scheme
参考文献
Bures, Filip; Cermakova, Hana; Kulhanek, Jiri; Ludwig, Miroslav; Kuznik, Wojciech; Kityk, Iwan V.; Mikysek, Tomas; Ruzicka, Ales
European Journal of Organic Chemistry, 2012 , # 3 p. 529 - 538
反应条件
1.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / Inert atmosphere
2.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere
2.2: 2 h / -78 - 25 °C / Inert atmosphere
3.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / 5 h / 50 °C / Inert atmosphere
View Scheme
参考文献
Bures, Filip; Cermakova, Hana; Kulhanek, Jiri; Ludwig, Miroslav; Kuznik, Wojciech; Kityk, Iwan V.; Mikysek, Tomas; Ruzicka, Ales
European Journal of Organic Chemistry, 2012 , # 3 p. 529 - 538
