1.1: i-PrMgCl / diethyl ether 1.2: 70 percent / HCl / methanol / 3 h / Heating 2.1: 85 percent / NaH / dimethylformamide / -10 - 20 °C 3.1: 84 percent / NiClCpIMes / diethyl ether / 0.17 h / 0 °C View Scheme

1: With isopropylmagnesium chloride in diethyl ether 2: With hydrogenchloride in methanol 3 h; Heating;

N,N,N',N,-tetramethylethylenediamine; iodine; sec.-butyllithium in tetrahydrofuran; cyclohexane T=-93 - 20°C;

1: 92 percent / NaH / dimethylformamide / -10 - 20 °C 2: 78 percent / TMEDA; s-BuLi; iodine / tetrahydrofuran; cyclohexane / -93 - 20 °C View Scheme