sodium t-butanolate; tri-tert-butyl phosphine; bis(dibenzylideneacetone)-palladium(0) in toluene T=80°C; 6 h;

1: potassium phosphate; trans-1,2diaminocyclohexane / copper(l) iodide / 1,4-dioxane / 20 h / 100 °C 2: sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium(0) / toluene / 8 h / 80 °C View Scheme

palladium diacetate; caesium carbonate; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene in toluene T=110°C; Buchwald-Hartwig Coupling; 6 h; Inert atmosphere;

1: potassium phosphate; trans-1,2diaminocyclohexane / copper(l) iodide / 1,4-dioxane / 20 h / 100 °C 2: sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium(0) / toluene / 8 h / 80 °C View Scheme

1: potassium carbonate; N,N'-dimethyl-N,N'-propyleneurea; 18-crown-6 ether / copper(l) iodide / 6 h / 180 °C / Inert atmosphere 2: sodium t-butanolate; tri-tert-butyl phosphine / bis(dibenzylideneacetone)-palladium(0) / toluene; hexane / 6 h / 80 °C / Inert atmosphere View Scheme

1.1: tris-(dibenzylideneacetone)dipalladium(0); 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene; potassium phosphate / toluene / 5 h / 100 °C / |Inert atmosphere 2.1: boron tribromide / dichloromethane / -78 - 20 °C 2.2: |Cooling with ice 3.1: pyridine / dichloromethane / 3 h / 0 °C / |Inert atmosphere 4.1: 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene; caesium carbonate; palladium diacetate / toluene / 6 h / 110 °C / |Inert atmosphere View Scheme

1.1: pyridine / dichloromethane / 3 h / 0 °C / |Inert atmosphere 2.1: tris-(dibenzylideneacetone)dipalladium(0); 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene; potassium phosphate / toluene / 5 h / 100 °C / |Inert atmosphere 3.1: boron tribromide / dichloromethane / -78 - 20 °C 3.2: |Cooling with ice 4.1: pyridine / dichloromethane / 3 h / 0 °C / |Inert atmosphere 5.1: 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene; caesium carbonate; palladium diacetate / toluene / 6 h / 110 °C / |Inert atmosphere View Scheme

1: pyridine / dichloromethane / 3 h / 0 °C / |Inert atmosphere 2: 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene; caesium carbonate; palladium diacetate / toluene / 6 h / 110 °C / |Inert atmosphere View Scheme

in acetonitrile 48 h; Photolysis;

in acetonitrile Kinetics;