3-乙酰基哌啶-1-羧酸叔丁酯合成路线 （共 5 条）
反应条件
1: in tetrahydrofuran T=0 - 20°C; 2: With potassium hydrogensulfate; water in tetrahydrofuran
参考文献
US2006/183761 A1, ;
Page/Page column 27 ;
US 20060183761 A1
反应条件
in tetrahydrofuran; diethyl ether T=0°C; 2 h;
参考文献
WO2011/117254 A1, ;
Page/Page column 33 ;
WO 2011/117254 A1
反应条件
tert-butyl methyl ether T=-10 - 20°C;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 19, # 4 p. 1159 - 1163
反应条件
1.1: 4-(N,N-dimethlyamino)pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.17 h 1.2: 16 h 2.1: diethyl ether; tetrahydrofuran / 2 h / 0 °C View Scheme
参考文献
WO2011/117254 A1, ;
WO 2011/117254 A1
反应条件
1: triethylamine; HATU / dichloromethane 2: diethyl ether; tetrahydrofuran / 0 - 20 °C View Scheme
参考文献
WO2012/58127 A2, ;
WO 2012/058127 A2
