3-乙酰基吡咯烷-1-羧酸叔丁酯合成路线 （共 4 条）
反应条件
1: With chloro-trimethyl-silane; lithium hexamethyldisilazane in tetrahydrofuran T=-78 - 0°C; 2: With N-bromosuccinmide in tetrahydrofuran T=0°C; 0.5 h;
参考文献
MERCK SHARP andamp; DOHME CORP.; OGAWA, Anthony; OK, Hyun, O.; ONDEYKA, Debra; UJJAINWALLA, Feroze; VANDE BUNTE, Ellen
Patent: WO2010/77624 A1, 2010 ;
Location in patent: Page/Page column 52 ;
WO 2010/077624 A1
反应条件
in tetrahydrofuran; diethyl ether
T=0°C;
参考文献
Henry, Christophe; Haupt, Andreas; Turner, Sean C.
Journal of Organic Chemistry, 2009 , vol. 74, # 5 p. 1932 - 1938
反应条件
methylmagnesium bromide in tetrahydrofuran; diethyl ether
T=-78 - 0°C; 4 h;
参考文献
MERCK SHARP andamp; DOHME CORP.; OGAWA, Anthony; OK, Hyun, O.; ONDEYKA, Debra; UJJAINWALLA, Feroze; VANDE BUNTE, Ellen
Patent: WO2010/77624 A1, 2010 ;
Location in patent: Page/Page column 50-51 ;
WO 2010/077624 A1
反应条件
1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 16 h / 20 °C
2: diethyl ether; tetrahydrofuran / 2.5 h / -78 - 0 °C
View Scheme
参考文献
Rodgers, James D.; Shepard, Stacey; Arvanitis, Argyrios G.; Wang, Haisheng; Storace, Louis; Folmer, Beverly; Shao, Lixin; Zhu, Wenyu; Glenn, Joseph
Patent: US2010/298334 A1, 2010 ;
US 20100298334 A1
