hydrogen; palladium 10 on activated carbon in ethyl acetate P=1551.49 Torr; 6 h;

1: acetophenone With lithium hexamethyldisilazane in tetrahydrofuran T=-78°C; 1 h; 2: 4-formyl-piperidine-1-carboxylic acid tert-butyl ester in tetrahydrofuran T=-78 - -30°C; 0.5 h; 3: With sodium hydrogencarbonate; methanesulfonyl chloride; triethylamine; citric acid more than 3 stages;

in tetrahydrofuran; hexane