2-氧代-1,2-二氢喹啉-3-羧酸乙酯合成路线 （共 16 条）
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide; ethylene glycol dimethyl ether; mineral oil / 0.25 h / 20 °C / Inert atmosphere
1.2: 0.25 h / 20 °C
1.3: 3 h / 20 - 60 °C
2.1: water; lithium hydroxide hydrate / 1,4-dioxane / 24 h / 20 °C
View Scheme
参考文献
IHARA CHEMICAL INDUSTRY CO., LTD.; KUMIAI CHEMICAL INDUSTRY CO., LTD.
Patent: US2011/287937 A1, 2011 ;
反应条件
1: 63.2 percent / sodium hydride / dimethylformamide / 8 h / 70 °C
2: 87.6 percent / 5 percent aq. NaOH / methanol / 18 h / 20 °C
View Scheme
参考文献
Ukrainets; Tkach; Kravtsova; Mamchur; Kovalenko
Chemistry of Heterocyclic Compounds, 2010 , vol. 46, # 7 p. 850 - 855
反应条件
1: 10.7 g / 96percent H2SO4, 70percent HNO3 / 1 h / 0 °C
2: 94 percent / 1.) 1 N NaOH; 2.) 1 N HCl / 1.25 h / Heating
View Scheme
参考文献
Hutt, Marland P.; MacKellar, Forrest A.
Journal of Heterocyclic Chemistry, 1984 , vol. 21, p. 349 - 352
反应条件
1: 10.7 g / 96percent H2SO4, 70percent HNO3 / 1 h / 0 °C
2: 94 percent / 1.) 1 N NaOH; 2.) 1 N HCl / 1.25 h / Heating
3: 18.3 g / H2 / Raney Ni / dimethylformamide
View Scheme
参考文献
Hutt, Marland P.; MacKellar, Forrest A.
Journal of Heterocyclic Chemistry, 1984 , vol. 21, p. 349 - 352
反应条件
1: 10.7 g / 96percent H2SO4, 70percent HNO3 / 1 h / 0 °C
2: 1.14 g / POCl3 / 2.75 h / Heating
View Scheme
参考文献
Hutt, Marland P.; MacKellar, Forrest A.
Journal of Heterocyclic Chemistry, 1984 , vol. 21, p. 349 - 352
反应条件
bromine in acetic acid
参考文献
Pfizer Inc.
Patent: US4710507 A1, 1987 ;
