2-氯-3-甲氧基苯胺盐酸盐合成路线 （共 5 条）
反应条件
hydrogenchloride in ethanol 6 h; Heating; Yield given;
参考文献
Journal of Medicinal Chemistry, , vol. 26, # 9 p. 1307 - 1311
反应条件
1: 1.) n-BuLi, 2.) hexachloroethane / 1.) THF, 0 deg C, 2 h, 2.) THF, from 0 deg C to RT, overnight 2: conc. HCl / ethanol / 6 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 26, # 9 p. 1307 - 1311
反应条件
1: trichlorophosphate / 16 h / Reflux 2: 6 h / 120 °C 3: potassium tert-butylate; water / dimethyl sulfoxide / 4 h / 140 °C View Scheme
参考文献
IDENIX PHARMACEUTICALS, INC.; PARSY, Christophe Claude; ALEXANDRE, Francois-Rene; LEROY, Frederic; CONVARD, Thierry; SURLERAUX, Dominique
Patent: WO2011/17389 A1, 2011 ;
WO 2011/017389 A1
参考文献
IDENIX PHARMACEUTICALS, INC.
Patent: US2012/207703 A1, 2012 ;
反应条件
trichlorophosphate 16 h; Heating / reflux;
参考文献
IDENIX PHARMACEUTICALS, INC.; PARSY, Christophe Claude; ALEXANDRE, Francois-Rene; LEROY, Frederic; CONVARD, Thierry; SURLERAUX, Dominique
Patent: WO2011/17389 A1, 2011 ;
Location in patent: Page/Page column 148-149 ;
WO 2011/017389 A1
