3-溴-8-氟-7-甲氧基-1-萘腈合成路线 （共 6 条）
反应条件
1-(chloromethyl)-4-fluoro-1,4-diazoniabicyclo-[2.2.2]octane bis(tetrafluoroborate) in acetonitrile
T=20°C;
参考文献
Mewshaw, Richard E.; Edsall Jr., Richard J.; Yang, Cuijian; Manas, Eric S.; Xu, Zhang B.; Henderson, Ruth A.; Keith Jr., James C.; Harris, Heather A.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 12 p. 3953 - 3979
反应条件
1.1: ZnI2 / benzene / 20 °C
1.2: POCl3; pyridine / benzene / 6 h / Heating
2.1: p-cymene / Pd/C / Heating
3.1: 0.88 g / C6H5N*HCl / 2 h / 190 °C
4.1: Br2; acetic acid / 6 h / 100 °C
4.2: aq. HCl; SnCl2 / 1 h / 100 °C
5.1: 2.41 g / K2CO3 / acetone / Heating
6.1: 13 percent / Selectfluor / acetonitrile / 20 °C
View Scheme
参考文献
Mewshaw, Richard E.; Edsall Jr., Richard J.; Yang, Cuijian; Manas, Eric S.; Xu, Zhang B.; Henderson, Ruth A.; Keith Jr., James C.; Harris, Heather A.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 12 p. 3953 - 3979
反应条件
1.1: p-cymene / Pd/C / Heating
2.1: 0.88 g / C6H5N*HCl / 2 h / 190 °C
3.1: Br2; acetic acid / 6 h / 100 °C
3.2: aq. HCl; SnCl2 / 1 h / 100 °C
4.1: 2.41 g / K2CO3 / acetone / Heating
5.1: 13 percent / Selectfluor / acetonitrile / 20 °C
View Scheme
参考文献
Mewshaw, Richard E.; Edsall Jr., Richard J.; Yang, Cuijian; Manas, Eric S.; Xu, Zhang B.; Henderson, Ruth A.; Keith Jr., James C.; Harris, Heather A.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 12 p. 3953 - 3979
反应条件
1: 2.41 g / K2CO3 / acetone / Heating
2: 13 percent / Selectfluor / acetonitrile / 20 °C
View Scheme
参考文献
Mewshaw, Richard E.; Edsall Jr., Richard J.; Yang, Cuijian; Manas, Eric S.; Xu, Zhang B.; Henderson, Ruth A.; Keith Jr., James C.; Harris, Heather A.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 12 p. 3953 - 3979
反应条件
1.1: Br2; acetic acid / 6 h / 100 °C
1.2: aq. HCl; SnCl2 / 1 h / 100 °C
2.1: 2.41 g / K2CO3 / acetone / Heating
3.1: 13 percent / Selectfluor / acetonitrile / 20 °C
View Scheme
参考文献
Mewshaw, Richard E.; Edsall Jr., Richard J.; Yang, Cuijian; Manas, Eric S.; Xu, Zhang B.; Henderson, Ruth A.; Keith Jr., James C.; Harris, Heather A.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 12 p. 3953 - 3979
反应条件
1.1: 0.88 g / C6H5N*HCl / 2 h / 190 °C
2.1: Br2; acetic acid / 6 h / 100 °C
2.2: aq. HCl; SnCl2 / 1 h / 100 °C
3.1: 2.41 g / K2CO3 / acetone / Heating
4.1: 13 percent / Selectfluor / acetonitrile / 20 °C
View Scheme
参考文献
Mewshaw, Richard E.; Edsall Jr., Richard J.; Yang, Cuijian; Manas, Eric S.; Xu, Zhang B.; Henderson, Ruth A.; Keith Jr., James C.; Harris, Heather A.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 12 p. 3953 - 3979
