1-(叔丁氧基羰基)-2-吡咯烷酮合成路线 （共 30 条）
反应条件
1: in tetrahydrofuran T=-78°C; 2 h; 2: With hydrogenchloride in tetrahydrofuran; water
参考文献
WO2006/44825 A2, ;
Page/Page column 55 ;
WO 2006/044825 A2
反应条件
in tetrahydrofuran T=-70 - 20°C;
参考文献
Organic Letters, , vol. 5, # 22 p. 4227 - 4230
反应条件
magnesium 1.) THF, 2.) -78 deg C; Yield given. Multistep reaction;
参考文献
Journal of Organic Chemistry, , vol. 54, # 1 p. 228 - 234
反应条件
D-glucose; K-phosphate buffer; Sphingomonas sp. HXN-200 T=30°C; pH=8.0; 5 h;
参考文献
Chang, Dongliang; Witholt, Bernard; Li, Zhi
Organic Letters, 2000 , vol. 2, # 24 p. 3949 - 3952
反应条件
1.1: LDA / tetrahydrofuran; hexane / 1.5 h / -78 °C 1.2: 68 percent / tetrahydrofuran; hexane / 0.25 h / -78 °C 2.1: 69 percent / pyridine; hydrogen peroxide / H2O; CH2Cl2 / 2 h / -78 - 20 °C View Scheme
参考文献
Le Vezouet, Ronan; White, Andrew J.P.; Burrows, Jeremy N.; Barrett, Anthony G.M.
Tetrahedron, 2006 , vol. 62, # 52 p. 12252 - 12263
反应条件
1: With lithium triethylborohydride in tetrahydrofuran; toluene
T=-70°C; 0.5 h;
2: With 4-(N,N-dimethlyamino)pyridine; N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride in tetrahydrofuran; toluene
T=-70 - 20°C; 2 h;
参考文献
Yu, Jurong; Truc, Vu; Riebel, Peter; Hierl, Elizabeth; Mudryk, Boguslaw
Tetrahedron Letters, 2005 , vol. 46, # 23 p. 4011 - 4013
反应条件
diisobutylaluminium hydride
T=-78°C;
参考文献
Yoshitomi, Yayoi; Arai, Hiromi; Makino, Kazuishi; Hamada, Yasumasa
Tetrahedron, 2008 , vol. 64, # 51 p. 11568 - 11579
反应条件
ammonium hydroxide
Heating;
参考文献
Carlier, Paul R; Chow, Ella S-H; Barlow, Rebecca L; Bloomquist, Jeffrey R
Bioorganic and medicinal chemistry letters, 2002 , vol. 12, # 15 p. 1985 - 1988
反应条件
lithium hexamethyldisilazane in tetrahydrofuran; cyclohexane
T=-78°C;
参考文献
Bogle, Katherine M.; Hirst, David J.; Dixon, Darren J.
Tetrahedron, 2010 , vol. 66, # 33 p. 6399 - 6410
反应条件
1: 100 percent / DIBALH / tetrahydrofuran / 1 h / -78 °C
2: 99 percent / toluene / 13 h / 100 °C
3: 76 percent / DIBALH / CH2Cl2 / 3 h / -78 °C
4: 92 percent / MnO2 / CH2Cl2 / 12 h / 23 °C
View Scheme
参考文献
Hara, Osamu; Sugimoto, Kazuhiko; Makino, Kazuishi; Hamada, Yasumasa
Synlett, 2004 , # 9 p. 1625 - 1627
