2-溴-7-甲氧基-3,4-二氢萘-1(2H)-酮合成路线 （共 7 条）
反应条件
bromine in chloroform 0.5 h;
参考文献
Brewster, William K.; Nichols, David E.; Watts, Val J.; Riggs, Robert M.; Mottola, Dave; Mailman, Richard B.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 2 p. 318 - 327
反应条件
Oxonereg;; NH4Br in methanol T=20°C; 2.5 h; regioselective reaction;
参考文献
Tetrahedron Letters, , vol. 53, # 2 p. 191 - 195
反应条件
lithium carbonate; lithium bromide in N,N-dimethyl-formamide 3.5 h; Heating; Yield given;
参考文献
Hulme, Alison N.; Henry, Steven S.; Meyers, A. I.
Journal of Organic Chemistry, 1995 , vol. 60, # 5 p. 1265 - 1270
反应条件
in N,N-dimethyl-formamide
6 h; Ambient temperature;
参考文献
Cozzi; Branzoli; Lovisolo; Orsini; Carganico; Pillan; Chiari
Journal of Medicinal Chemistry, 1986 , vol. 29, # 3 p. 404 - 410
反应条件
1: 44 percent / dimethylformamide / 16 h / Ambient temperature
2: NaBH4 / methanol / 2 h / Ambient temperature
View Scheme
参考文献
Hartmann, Rolf W.; Frotscher, Martin; Ledergerber, Dorothea; Waechter, Gerald A.; Gruen, Gertrud L.; Sergejew, Tom F.
Archiv der Pharmazie, 1996 , vol. 329, # 5 p. 251 - 261
反应条件
1: 44 percent / dimethylformamide / 16 h / Ambient temperature
2: NaBH4 / methanol / 2 h / Ambient temperature
3: conc. H2SO4, glac. HOAc / 4 h / 100 °C
View Scheme
参考文献
Hartmann, Rolf W.; Frotscher, Martin; Ledergerber, Dorothea; Waechter, Gerald A.; Gruen, Gertrud L.; Sergejew, Tom F.
Archiv der Pharmazie, 1996 , vol. 329, # 5 p. 251 - 261
反应条件
1: 44 percent / dimethylformamide / 16 h / Ambient temperature
2: 53 percent / H2, 70percent HClO4 / 10percent Pd/C / acetic acid / 85 °C / 3750.3 Torr
View Scheme
参考文献
Hartmann, Rolf W.; Frotscher, Martin; Ledergerber, Dorothea; Waechter, Gerald A.; Gruen, Gertrud L.; Sergejew, Tom F.
Archiv der Pharmazie, 1996 , vol. 329, # 5 p. 251 - 261
